Browse > Article

Sedative and Antinociceptive Properties of Lindera obtusiloba  

Lee, Yong Jae (College of Pharmacy, Woosuk University)
Lee, Dong Keon (College of Pharmacy, Woosuk University)
Kim, Jong Soo (College of Pharmacy, Woosuk University)
Park, Kyoung Jae (College of Pharmacy, Woosuk University)
Cha, Dong Seok (College of Pharmacy, Woosuk University)
Kim, Dae Keun (College of Pharmacy, Woosuk University)
Kwon, Jin (Department of Prosthetics and Orthotics, Korea National College of Rehabilitation and Welfare)
Oh, Chan Ho (Department of Biotechnology, Graduate School, Woosuk University)
Kim, Kang San (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
Jeon, Hoon (College of Pharmacy, Woosuk University)
Publication Information
Natural Product Sciences / v.18, no.4, 2012 , pp. 215-220 More about this Journal
Abstract
The stem of Lindera obtusiloba (Lauraceae), has been widely used as a traditional medicine for the treatment of abdominal pain, bruise and hepatocirrhosis. In the present study, antinociceptive and sedative properties of the methanol extract of L. obtusiloba (MLO) were evaluated. MLO demonstrated strong and dose-dependent antinociceptive activities on various experimental pain models including thermal nociception and chemical nociception, compared to tramadol and indomethacin, reference drugs. In combination test using naloxone, the diminished analgesic activity of MLO was observed, indicating the relation with opioid receptor. Moreover, MLO also decreases pentobarbital-induced sleep latency and increases sleeping time suggesting its hypnotic and sedative action. The present results indicate that MLO could be used as valuable antinociceptive and sedative agent for the treatment of various diseases.
Keywords
Lindera obtusiloba; Sedative; Antinociceptive;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Bley, K.R., Hunter, J.C., Eglen, R.M., and Smith, J.A., The role of IP prostanoid receptors in inflammatory pain. Trends Pharmacol. Sci. 19, 141-147 (1998)   DOI   ScienceOn
2 Bruce, R.D., An up-and-down procedure for acute toxicity testing. Fundam. Appl. Toxicol. 5, 151-157 (1985).   DOI   ScienceOn
3 Calixto, J.B., Beirith, A., Ferreira, J., Santos, A.R., Filho, V.C., and Yunes, R.A., Naturally occurring antinociceptive substances from plants. Phytother. Res. 14, 401-418 (2000).   DOI   ScienceOn
4 Dalal, A., Tata, M., Allegre, G., Gekiere, F., Bons, N., and Albe-Fessard, D., Spontaneous activity of rat dorsal horn cells in spinal segments of sciatic projection following transections of sciatic nerve or of corresponding dorsal roots. Neuroscience 94, 217-228 (1999).   DOI   ScienceOn
5 Dandiya, P.C. and Collumbine, H., Studies on Acarus calamus: (III). Some pharmacological actions on the volatile oil. J. Pharmacol. Exp. Ther. 125, 353-359 (1959).
6 Derardt, R., Jougney, S., Delevalcee, F., and Falhout, M., Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur. J. Pharmacol. 51, 17-24. (1980).
7 Dirig, D.M., Isakson, P.C., and Yaksh, T.L., Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. J. Pharmacol. Exp. Ther. 285, 1031-1038 (1998).
8 Franzotti, E.M., Santos, C.V., Rodrigues, H.M., Mourão, R.H., Andrade, M.R., and Antoniolli, A.R., Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca). J. Ethnopharmacol. 72, 273-277 (2000).   DOI   ScienceOn
9 Freise, C., Erben, U., Neuman, U., Kim, K., Zeitz, M., Somasundaram, R., and Ruehl, M., An active extract of Lindera obtusiloba inhibits adipogenesis via sustained Wnt signaling and exerts anti-inflammatory effects in the 3T3-L1 preadipocytes. J.Nutr.Biochem. 21, 2009-2995. (2010).
10 Fukawa, K., Kawano, O., Hibi, M., Misaki, N., Ohba, S., and Hatanaka, Y., A method for evaluating analgesic agents in rats. J. Pharmacol. Methods 4, 251-259 (1980).   DOI   ScienceOn
11 Gouemo, P.N., Nguemby-bina, C., and Baldt-Mouliner, M., Some neuropharmacological effects of an ethanolic extract of Maprounea africana in rodents. J.Ethnopharmacol. 62, 57-263 (1994).
12 Amaral, J.F., Silva, M.I.G., Neto, M.R.A., Neto, P.F.T., Moura, B.A., Melo, C.T.V., Araújo, F.LO., DeSousa, D.P., Vasconcelos, P.F., Vasconcelos, S.M., and Sousa, F.C.F., Antinociceptive effect of the monoterpene R-(-)-limoneneinmice. Biol. Pharm. Bull. 30, 1217-1220 (2007).   DOI   ScienceOn
13 Hunskaar, S., Fasmer, O.B., and Hole, K., Formalin test in mice, a useful technique for evaluating mild analgesics. J.Neurosci.Methods 14, 69-76 (1985).   DOI   ScienceOn
14 Kaul, P.N. and Kulkarni, S.K., New drug metabolism inhibitor of marine origin. J.Pharm.Sci. 67, 1293-1296 (1978).   DOI
15 Kim, S.H., Son, J.H., and Lee, S.H., Inhibitory effects of water extract of Lindera obtusiloba on the mast cell-mediated allergic inflammation. Kor. J. Pharmacogn. 40, 233-237 (2009).
16 Komae, H. and Hayashi, H., Phytosterols of the trunks of Lindera obtusiloba. Phytochemistry 11, 1182 (1972).   DOI   ScienceOn
17 Kwon, H.C., Choi, S.U., Lee, J.O., Bae, K.H., Zee, O.P., and Lee, K.R., Two new lignans from Lindera obtusiloba Blume. Arch.Pharm.Res. 22, 417-422 (1999).   DOI   ScienceOn
18 Lee, K.Y., Kim, S.H., Jeong, E.J., Park, J.H., Kim, S.H., Kim, Y.C., and Sung, S.H., New secoisolariciresinol derivatives from Lindera obtusiloba stems and their neuroprotective activities. Planta. Med. 76, 294-297 (2010).   DOI   ScienceOn
19 Li, Q., Chou, G., Dou, C., Wang, Z., and Huang, F., Studies on the analgesic and anti-inflammatory action of Radix Linderae extract. Zhong Yao Cai 20, 629-631 (1997).
20 Niwa, M., Iguchi, M., and Yamamura, S., Three new obtusilactones from Lindera obtusiloba Blume. Chem. Lett. 4, 655-658 (1975).
21 Olajide, O.A., Awe, S.O., Makinde, J.M., Ekhelar, A.I., Olusola, A., Morebise, O., and Okpako, D.T., Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark. J.Ethnopharmacol. 71, 179-186 (2000).   DOI   ScienceOn
22 Ozturk, Y., Aydini, S., Beis, R., Baser, K.H.C, and Berberoglu, H., Effect of Hypericum pericum L. and Hypericum calycinum L. extracts on the central nervous system in mice. Phytomedicine 3, 139-146 (1996).   DOI   ScienceOn
23 Ruehl, M., Erben, U., Kim, K., Freise, C., Dagdelen, T., Eisele, S., Trowitzsch-Kienast, W., Zeitz, M., Jia, J., Stickel, F., and Somasundaram, R., Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-beta-mediated profibrotic gene expression pattern. J. Nutr. Biochem. 20, 597-606 (2009).   DOI   ScienceOn
24 Santos, A.R.S. and Calixto, J.B., Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice. Neuropeptides 31, 381-389 (1997).   DOI   ScienceOn
25 Trongsakul, S., Panthong, A., Kanjanapothi, D., and Taesotikul, T., The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz. J. Ethnopharmacol. 85, 221-225 (2003).   DOI   ScienceOn
26 Vontagu, H., Abbah, J., Nagazal, I.E., Kunle, O.F., Chindo, B.A., Otsapa, P.B., and Gamaniel, K.S., Antinociceptive and anti-inflammatory activities of the methanolic extract of Parinari polyandra stem bark in rats and mice. J. Ethnopharmacol. 90, 115-121 (2004).   DOI   ScienceOn
27 Wang, Y.X., Gao, D., Pettus, M., Phillips, C., and Bowersox, S.S., Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. Pain 84, 271-281 (2000).   DOI   ScienceOn
28 Yook, C., Lindera obtusiloba. Medical plants of Korea. Seoul 184 (1989).
29 Zhao, Q., Zhao, Y., and Wang, K., Antinociceptive and free radical scavenging activities of alkaloids isolated from Lindera angustifolia Chen. J. Ethnopharmacol. 106, 408-413 (2006).   DOI   ScienceOn
30 Zimmermann, M., Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16, 109-110 (1983).   DOI   ScienceOn