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Effects of Extract and Isorhamnetin Glycoside from Brassica juncea on Hepatic Alcohol-Metabolizing Enzyme System in Rats  

Hur, Jong-Moon (Research Institute of Korean Oriental Medicine, Sunchon National University)
Park, Sang-Hyun (Research Institute of Korean Oriental Medicine, Sunchon National University)
Choi, Jong-Won (Department of Pharmacy, Kyungsung University)
Park, Jong-Cheol (Research Institute of Korean Oriental Medicine, Sunchon National University)
Publication Information
Natural Product Sciences / v.18, no.3, 2012 , pp. 190-194 More about this Journal
Abstract
The effects of methanol extract of the leaves of Brassica juncea and its major component, isorhamnetin 3-O-${\beta}$-D-glucopyranoside on hepatic alcohol metabolizing enzymes were investigated. The methanol extract and isorhamnetin 3-O-${\beta}$-D-glucopyranoside supplementations increased the activities of microsomal ethanol oxidizing system and aldehyde dehydrogenase in a dose-dependent manner, and had mild effects on the activities of alcohol dehydrogenase and catalase. Isorhamnetin 3-O-${\beta}$-D-glucopyranoside alleviated the adverse effect of ethanol ingestion by enhancing the activities of alcohol oxidizing emzymes, microsomal ethanol oxidizing system and aldehyde dehydrogenase.
Keywords
Alcohol detoxification; Isorhamnetin 3-O-${\beta}$-D-glucopyranoside; Microsomal ethanol oxidizing system; Aldehyde dehydrogenase; Brassica juncea;
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1 Abei, H., in Bergmeyer M.U. (eds.), in Academic Press, Catalase. In Methods of Enzymatic Analysis, Vol. 2. New York, pp. 673-682, 1974.
2 Ahmed, M.S.E.I., Tanbouly, N.D., Islam, W.T., Sleem, A.A.E.I., and Senousy, A.S., Antiinflammatory flavonoids from Opuntia dillenii (Ker-Gawl) Haw. Flowers growing in Egypt. Phytother. Res. 19, 807-809 (2005).   DOI   ScienceOn
3 Akbay, P., Basaran, A.A., Undeger, U., and Basaran, N., In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L. Phytother. Res. 17, 34-37 (2003).   DOI   ScienceOn
4 Borson, W.F., Li, T.K., and Lange, L.G., Isolation and characterization of an anodic from a human liver alcohol dehydrogenase. Biochem. Biophys. Res. Commm. 27, 554-561 (1977).
5 Conway, D.I., Alcohol consumption and the risk for disease. Evid. Based Dent. 6, 76-77 (2005).   DOI   ScienceOn
6 DeMaster, E.G., Kaplan, E., and Chesler, E., The differential response of tissue catalase activity to chronic alcohol administration in the rat. Alcohol Clin. Exp. Res. 5, 45-48 (1981).
7 Hur, J.M. and Park, J.C., Effects of the aerial parts of Orostachys japonicus and its bioactive component on hepatic alcohol-metabolizing enzyme system. J. Med. Food 9, 336-341 (2006).   DOI   ScienceOn
8 Hur, J.M., Choi, J.W., and Park, J.C., Effects of the methanol extract of the leaves of Brassica juncea and its major component, isorhamnetin 3-O-${\beta}$-D-glucoside, on hepatic drug metabolizing enzymes in bromobenzene-treated rats. Food Sci. Biotechnol. 16, 439-443 (2007).
9 Inoue, K., Fukunaga, M., and Yamasawa, K., Correlation between human erythrocyte aldehyde dehydrogenase activity and sensitivity to alcohol. Pharmacol. Biochem. Behav. 13, 295-297 (1980).   DOI   ScienceOn
10 Lecomte, E.B., Herberth, P., and Pirollet, Y., Effect of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators. Am. J. Clin. Nutr. 60, 225-261 (1994).
11 Lieber, C.S. and DeCarli, L.M., Quantitative relationship between amount of dietary fat and severity of alcoholic fatty liver. Am. J. Clin. Nutr. 23, 474-478 (1970a).   DOI
12 Lieber, C.S. and De Carli, L.M., Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo. J. Biol. Chem. 245, 2505-2512 (1970b).
13 Lieber, C.S., Microsomal ethanol-oxidizing system. Enzyme 37, 45-56 (1987).   DOI
14 Lim, S.S., Jung, Y.J., Hyun, S.K., Lee, Y.S., and Choi, J.S., Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera. Phytother. Res. 20, 825-830 (2006).   DOI   ScienceOn
15 Lluis, J.M., Colell, A., Garcia-Ruiz, Kaplowitz, N., and Fernndesz-checa, J.C. Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology 124, 708-772 (2003).   DOI   ScienceOn
16 Lowry, O.H., Rosenbrough, N.J., Farr, A.L., and Randall, R.J., Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265-275 (1951).
17 Niemelo, O., Parkkila, S., Yla-Herttuala, S., Halsted, C., Witztum, J.L., Lanca, A., and Israel, Y., Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation. Lab. Invest. 70, 537-546 (1994).
18 Park, J.C., Hur, J.M., Park, J.G., Kim, S.C., Park, J.R., Choi, S.H., and Choi, J.W., Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin 7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats. Phytother. Res. 18, 19-24 (2004).   DOI   ScienceOn
19 Pearson, T.A., Alcohol and heart disease. Circulation 94, 3023-3025 (1996).   DOI   ScienceOn
20 Poschl, G. and Seitz, H.K., Alcohol and cancer. Alcohol Alcohol 39, 155-165 (2005).
21 Rezvani, A.H., Overstreet, D.H., Yang, Y., and Clark, E. Jr., Attenuation of alcohol intake by extract of Hypericum perforatum (St. John's Wort) in two different strains of alcohol-preferring rats. Alcohol Alcohol 34, 699-705 (1999).   DOI
22 Rezvani, A.H., Overstreet, D.H., Perfumi, M., and Massi, M., Plant derivatives in the treatment of alcohol dependency. Pharmacol. Biochem. Behav. 75, 593-606 (2003).   DOI   ScienceOn
23 Seitz, H.K. and Becker, P., Alcohol metabolism and cancer risk. Alcohol Res. Health 30, 38-47 (2007).
24 Tsukamoto, H., Towner, S.J., Ciofalo, L.M., and French, S.W., Ethanolinduced liver fibrosis in rats fed high fat diet. Hepatology 6, 814-822 (1986).   DOI
25 Wijeratne, S.S., Abou-Zaid, M.M., and Shahidi, F., Antioxidant polyphenols in almond and its coproducts. J. Agric. Food Chem. 25, 312-318 (2006).