[KSCI] Korea Science Citation Index Service

Cyclooxgenase Inhibitory Components from Portulaca oleracea

Kim, Jeong-Ah (College of Pharmacy, Chungnam National University)
Yang, Seo-Young (College of Pharmacy, Chungnam National University)
Kang, Sang-Jin (Department of Applied Bioscience, CHA University)
Kim, Young-Ho (College of Pharmacy, Chungnam National University)

Publication Information

Natural Product Sciences / v.18, no.1, 2012 , pp. 22-25 More about this Journal

Abstract

Five triterpenoids, epifriedelanol (1), friedelin (2), lupeol (3), ${\beta}$ -sitosterol (4), daucosterol (5), and one phenyl propanoids ester, trans-docosanoyl ferulate (6) were isolated from the whole parts of Portulaca oleracea. They were determined using a combination of spectroscopic analyses ( $^1H-$ , $^{13}C$ -NMR, and MS data) and evaluated for their cyclooxygenase inhibitory activity. Compound 6 exhibited inhibitory effect with $IC_{50}$ values of $40.2{\mu}M$ and 1.6 mM on COX-1 and COX-2 activities, respectively.

Keywords

Portulaca oleracea; cyclooxygenase inhibitory activity; trans-docosanoyl ferulate;

Citations & Related Records

Times Cited By KSCI : 1 (Citation Analysis)

Reference
Cited By KSCI

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