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Analysis of the Components of Guibitang and Fermented Guibi-tang and their Ability to Inhibit Angiotensin-converting Enzyme  

Liang, Chun (TKM Converging Research Division, Korea Institute of Oriental Medicine)
Yun, Na-Young (TKM Converging Research Division, Korea Institute of Oriental Medicine)
Jung, Sang-Won (TKM Converging Research Division, Korea Institute of Oriental Medicine)
Kim, Dong-Seon (TKM Converging Research Division, Korea Institute of Oriental Medicine)
Lee, Young-Jae (College of Veterinary Medicine, Jeju National University)
Ma, Jin-Yeul (TKM Converging Research Division, Korea Institute of Oriental Medicine)
Publication Information
Natural Product Sciences / v.17, no.4, 2011 , pp. 363-366 More about this Journal
Abstract
Guibi-tang is a traditional medicine used for the treatment of colds. We investigated the levels of several compounds in Guibi-tang before and after fermentation with Lactobacillus and tested their ability to inhibit angiotensin-converting enzyme. Six known compounds (decursin, decursinol angelate, nodakenin, liquiritin, formononetin, and 6-gingerol) and 2 unidentified compounds were detected in Guibi-tang (GB) and fermented Guibi-tang (FGB) by an established HPLC-DAD method. The levels of the 6 known compounds were decreased after fermentation. FGB showed more potent inhibition of angiotensin-converting enzyme activity than GB. In conclusion, fermentation with Lactobacillus affects the content of several compounds in GB and improves its angiotensin-converting enzyme inhibitory activity.
Keywords
Guibi-tang; fermentation; angiotensin-converting enzyme;
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Times Cited By KSCI : 3  (Citation Analysis)
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