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Superoxide Quenching Activity of Phenolic Compounds from the Whole Plant of Galium verum var. asiaticum  

Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Publication Information
Natural Product Sciences / v.17, no.4, 2011 , pp. 261-266 More about this Journal
Abstract
During the process of screening for antioxidative effects of natural plants in Korea, by measuring the superoxide quenching activity, methanol extract of the whole plant, Galium verum var. asiaticum (Rubiaceae), was found to show potent antioxidant activity. Subsequent activity-guided fractionation of methanol extract of Galium verum var. asiaticum led to the isolation of five phenolic compounds. Using spectroscopic techniques, the chemical structures were elucidated as: caffeic acid (1), narcissin (2), rutin (3), luteolin-7-O-${\alpha}$-L-rhamnopyranosyl (1 ${\rightarrow}$ 2)-${\beta}$-D-glucopyranoside (4), and luteolin-7-O-${\beta}$-D-glucopyranoside (5). These compounds were isolated for the first time from this plant. Among them, compound 1 showed the most significant riboflavin-originated superoxide and xanthine-originated superoxide quenching activities. Compounds 3 and 4 exhibited mild superoxide quenching effects compared with vitamine C.
Keywords
Galium verum var. asiaticum; Rubiaceae; superoxide quenching activity;
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