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Inhibition of Rat Lense Aldose Reductase by Flavonoids from Dandelions  

Mok, So-Youn (Department of Integrative Plant Science, Chung-Ang University)
Lee, Sul-Lim (Department of Integrative Plant Science, Chung-Ang University)
Kim, Hye-Min (Department of Integrative Plant Science, Chung-Ang University)
Lee, Jeong-Min (Department of Integrative Plant Science, Chung-Ang University)
Lee, Dong-Gu (Department of Integrative Plant Science, Chung-Ang University)
Ahn, Young-Hee (Department of Integrative Plant Science, Chung-Ang University)
Park, Chun-Geon (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Cho, Eun-Ju (Department of Food Science and Nutrition, Pusan National University)
Lee, Sang-Hyun (Department of Integrative Plant Science, Chung-Ang University)
Publication Information
Natural Product Sciences / v.17, no.2, 2011 , pp. 130-134 More about this Journal
Abstract
The purpose of this study was to evaluate the therapeutic potential of naturally occurring aldose reductase (AR) inhibitors isolated from Korean native plants. The MeOH extract and stepwise polarity fractions of dandelions were tested on rat lens AR inhibition in vitro. Of these, the EtOAc fractions from the leaves of dandelions (Traxacum coreanum, T. officinale, and T. ohwianum) exhibited an AR inhibitory activity ($IC_{50}$ values, 2.37, 1.73 and 2.68 ${\mu}g/ml$, respectively). A chromatography of the EtOAc fraction from the leaves of T. coreanum led to the further isolation of two flavonoids identified as luteolin and luteolin 7-O-glucopyranoside. These compounds exhibited strong AR inhibitory activity, with $IC_{50}$ values of 0.15 and 1.05 ${\mu}M$, respectively. These results suggested that luteolin is a potent AR inhibitor within dandelions and that it could be a useful lead compound in the development of a novel AR inhibitory agent against diabetic complications.
Keywords
Aldose reductase inhibitory activity; Dandelion; Diabetic complications; Luteolin; Luteolin 7-Oglucopyranoside;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
Times Cited By SCOPUS : 2
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