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Arginase II Inhibitory Activity from Crude Drugs  

Lim, Chae-Jin (College of Pharmacy, Catholic University of Daegu)
Hung, Tran Manh (Faculty of Chemistry, University of Natural Sciences, National University Hochiminh city)
Ryoo, Sung-Woo (Kangwon National University)
Lee, Jeong-Hyung (Kangwon National University)
Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.17, no.2, 2011 , pp. 113-116 More about this Journal
Abstract
Arginase competitively inhibits nitric oxide synthase (NOS) via use of the common substrate L-arginine. Arginase II has recently reported as a novel therapeutic target for the treatment of cardiovascular diseases such as atherosclerosis. In our experiment, the EtOH extracts of four-hundreds extracts drugs were investigated for the arginase inhibitory activity. Among them, four extracts exhibited over 50% inhibition of arginase II activity compared to control at a concentration of 150${\mu}g/ml$. In particular, the seed of Arctium lappa, gum-resin of Boswellia carterii, aerial part of Artemisia apiacea and rhizome of Cyperus rotundus inhibited arginase II activity, with $IC_{50}$ values of 118.4, 135.4, 123.9 and 86.7${\mu}g/ml$, respectively. In addition, four plant extracts showed less than 20% inhibition of arginase I activity at 150${\mu}g/ml$. These plants might be the potential candidate materials in the development of the novel atherosclerosis drug.
Keywords
Arginase II; Crude drug; Atherosclerosis; Cyperus rotundus;
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