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Inhibition of Aldose Reductase from Rat Lenses by Methanol Extracts from Korean Folk Plants  

Kim, Hye-Min (Department of Applied Plant Science, Chung-Ang University)
Mok, So-Youn (Department of Applied Plant Science, Chung-Ang University)
Lee, Jeong-Min (Department of Applied Plant Science, Chung-Ang University)
Cho, Eun-Ju (Department of Food Science and Nutrition, Pusan National University)
Choi, Kyung (Department of Forest Resource Conservation, Korea National Arboretum)
Ku, Ja-Jung (Department of Forest Resource Conservation, Korea National Arboretum)
Park, Kwang-Woo (Department of Forest Resource Conservation, Korea National Arboretum)
Lee, Sang-Hyun (Department of Applied Plant Science, Chung-Ang University)
Publication Information
Natural Product Sciences / v.16, no.4, 2010 , pp. 285-290 More about this Journal
Abstract
The inhibition of rat lens aldose reductase (AR) in vitro using methanol extracts from Korean folk plants was investigated. Among them, the extracts of Saussurea grandifolia and Rumex crispus showed highest inhibition of AR. $IC_{50}$ values of the extracts from S. grandifolia and R. crispus were demonstrated 0.07 and 0.05 mg/ml, respectively. Korean folk plants such as S. grandifolia and R. crispus has a possibility of new natural resources for the inhibition of AR.
Keywords
Korean folk plant; rat lens aldose reductase; diabetic complications;
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1 Kawanishi, K., Ueda, H., and Moriyasu, M., Aldose reductase inhibitors from the nature. Curr. Med. Chem.10, 1353-1374 (2003).   DOI   ScienceOn
2 Sun, W., Oates, P.J., Coutcher, J.B., Gerhardinger, C., and Lorenzi, M., A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy. Diabetes 55, 2757-2762 (2006).   DOI   ScienceOn
3 Constantino, L., Rastelli, G., Vianello, P., Cignarella, G., and Barlocco, D., Diabetes complications and their potential prevention: aldose reductase inhibition and other approaches. Med. Res. Rev. 19, 3-23 (1999).   DOI   ScienceOn
4 Ward, J.D., Advance in metabolic disorders (suppl. 2): The polyol pathway in the neuropathy of early diabetes, Academic press, New York, 1973, p. 425.
5 Maksimovie, Z., Kovacevic, N., Lakusic, B., and Cebovic, T., Antioxidant activity of yellow dock (Rumex crispus L., Polygonaceae) fruit extract. Phytother Res. Published online in Wiley Inter Science (2010).
6 Matsumoto, T., Ono, Y., Kurono, M., Kuromiya, A., Nakamura, K., and Bril, V., Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats. J. Pharmacol. Sci. 107, 231-237 (2008).   DOI   ScienceOn
7 Nugroho, A., Kim, K.H., Lee, K.R., Alam, M.B., Choi, J.S., Kim, W.B., and Park, H.J., Qualitative and quantitative determination of the caffeoylquinic acids on the Korean mountainous vegetables used for chwinamul and their peroxynitrite-scavenging effect. Arch. Pharm. Res. 35, 1361-1367 (2009).   과학기술학회마을
8 Teixeira da Silva, J.M., Mining the essential oils of the Anthemideae. African J. Biotechnol. 3, 706-720 (2004).
9 Van Heyningen, R., Formation of polyol by the lens of the rat with sugar cataract. Nature 184, 194-196 (1959).
10 Wiese, B., Quiroga, O.E., Vigo, M.S., and Nolasco, S.M., Chemical composition of Rumex crispus L. seed. JAOCS. 72, 1077-1078 (1995).   DOI   ScienceOn
11 Ziegler, D., Polyneuropathy in the diabetic patient-updata on pathogenesis and management. Nephrol. Dial. Transplant 19, 2170-2175 (2004).   DOI   ScienceOn
12 Engerman, R.L. and Kern, T.S., Experimental galactosemia produces diabetic-like retinopathy. Diabetes 33, 97-100 (1984).   DOI   ScienceOn
13 Ko, K.S. and Jeon, U.S., Ferns, Fern-Allies and Seed-Bearing Plants of Korea, Iljinsa, Korea, 1983, p. 656-674.
14 Lee, S., Kim, D., Yim, D., and Lee S., Anti-inflammatory, analgesic and hepatoprotective effect of Semen of Rumex crispus. Kor. J. Pharmacogn. 38, 334-338 (2007).   과학기술학회마을
15 Chalk, C., Benstead, T.J., and Moore, F., Aldose reductase inhibitors for the treatment of diabetic polyneuropathy. Cochrane Database Syst. Rev. 4, CD004572 (2007).
16 Drel, V.R., Pacher, P., Ali, T.K., Shin, J., Julius, U., El-Remessy, A.B., and Obrosova, I.G., Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis. Int. J. Mol. Med. 21, 667-676 (2008).
17 De la Fuente, J.A. and Manzanaro, S., Aldose reductase inhibitors from natural sources. Nat. Prod. Rep. 20, 243-251 (2003).   DOI   ScienceOn
18 Fan, J.P. and Zhang, Z.L., Studies on the chemical constituents of Rumex crispus. Zhong Yao Cai 32, 1836-1840 (2009).
19 Hotta, N., Akanuma, Y., Kawamori, R., Matsuoka, K., Oka, Y., Shichiri, M., Toyata, T., Nakashima, M., Yoshimura, I., Sakamoto, N., and Shigeta, Y., Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy. Diabetes Care 29, 1538-1544 (2006).   DOI   ScienceOn
20 Kim, M., Korean Endemic Plants, Solbook Press, Korea, 2004, p. 12-16.
21 Beyer-Mears, A., Ku, L., and Cohen, M., Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil. Diabetes 33, 604-607 (1984).   DOI   ScienceOn
22 Baskan, S., Daut-Ozdemir, A., Gunaydin, K., and Erim, F.B., Analysis of anthraquinones in Rumex crispus by micellar electrokinetic chromatography. Talanta 71, 747-750 (2007).   DOI   ScienceOn
23 Beyer-Mears, A. and Cruz, E., Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. Diabetes 34, 15-21 (1985).   DOI   ScienceOn