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Bamboo Culm Extract Attenuates Early Development of Systemic Inflammation in Pristane-Primed Lupus Mice  

Chae, Byeong-Suk (College of Pharmacy, Woosuk University)
Publication Information
Natural Product Sciences / v.16, no.4, 2010 , pp. 271-279 More about this Journal
Abstract
Systemic lupus erythematosus (SLE) is characterized by systemic inflammation through production of inflammatory mediators and signaling abnormalities between T- and B- cells, leading to autoantibody production and multiorgan injuries. This study was investigated whether bamboo culm extract (BC) attenuates development of lupus systemic inflammation in the early stage in pristane-induced lupus mice. The pristane-induced lupus mice were administrated with BC 0.5 ml/kg or PBS and healthy mice with PBS orally once a day for 14 days. Our results showed that BC remarkably attenuated levels of serum TNF-$\alpha$, IL-6, IL-10, IFN-$\gamma$, $PGE_2$, and VEGF, production of macrophages IL-6 and $PGE_2$ and expression of macrophages IL-6 and COX-2 mRNA in the presence or absence of LPS in pristane-induced lupus mice. Also, BC remarkably reduced expression of CD40L on the splenic T cells and CD80 on the splenic B cells and upregulated the reduced apoptosis of splenic T cells and CD4+ T cells in pristane-induced lupus mice. Therefore, these findings suggest that BC may attenuate early development of lupus systemic inflammation via downregulation of inflammatory mediators and amelioration of abnormal signaling between T cells and B cells.
Keywords
Bamboo culm; $PGE_2$; lupus; proinflammatory cytokine; VEGF; costimulatory molecule;
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1 Ito, Y., Akao, Y., Shimazawa, M., Seki, N., Nozawa, Y., and Hara, H., Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity. CNS Drug Rev., 13, 296-307 (2007).   DOI   ScienceOn
2 Llorente, L., Zou, W., Levy, Y., Richaud-Patin, J., Wijdenes, J., Alcocer- Varela, J., Morel-Fourrier, B., Brouet, J.C., Alarcon-Segovia, D., Galanaud, P., and Emilie, D., Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J. Exp. Med. 181, 839-844 (1995).   DOI   ScienceOn
3 Yazdany, J. and Davis, J., The role of CD40 ligand in systemic lupus erythematosus. Lupus 13, 377-380 (2004).   DOI   ScienceOn
4 Ishihara, K. and Hirano, T., IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 13, 357-368 (2002).   DOI   ScienceOn
5 Chun, H.Y., Chung, J.W., Kim, H.A., Yun, J.M., Jeon, J.Y., Ye, Y.M., Kim, S.H., Park, H.S. and Suh, C.H., Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J. Clin. Immunol. 27, 461-466 (2007).   DOI   ScienceOn
6 Theofilopoulos, A.N., Koundouris, S., Kono, D.H., and Lawson, B.R., The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity. Arthritis Res. 3, 136-141 (2001).   DOI   ScienceOn
7 Wu, Y., Xu, J., Shinde, S., Grewal, I., Henderson, T., Flavell, R.A., and Liu, Y., Rapid induction of a novel costimulatory activity on B cells by CD40 ligand. Curr. Biol. 5, 1303-1311 (1995).   DOI   ScienceOn
8 Xu, L., Zhang, L., Yi, Y., Kang, H.K. and Datta, S.K., Human lupus T cells resist inactivation and escape death by upregulating COX-2. Nat. Med. 10, 411-415 (2004).   DOI   ScienceOn
9 Kyttaris, V.C., Juang, Y.T., and Tsokos, G.C., Immune cells and cytokines in systemic lupus erythematosus: an update. Curr. Opin. Rheumatol. 17, 518-522 (2005).   DOI   ScienceOn
10 Lee, M.J., Park, W.H., Song, Y.S., Lee, Y.W., Song, Y.O., and Moon, G.S., Effect of bamboo culm extract on oxidative stress and genetic expression: bamboo culm extract ameliorates cell adhesion molecule expression and NFkappaB activity through suppression of the oxidative stress. Clin Nutr. 27(5), 755-763 (2008).   DOI   ScienceOn
11 Liang, B., Gardner, D.B., Griswold, D.E., Bugelski, P.J., and Song, X.Y., Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus. Immunology 119(3), 296-305 (2006).   DOI   ScienceOn
12 Chae, B.S., Shin, T.Y., Kim, D.K., Eun, J.S., Leem, J.Y., and Yang, J.H., Prostaglandin E2-mediated dysregulation of proinflammatory cytokine production in pristane-induced lupus mice. Arch. Pharm. Res. 31, 503-510 (2008).   과학기술학회마을   DOI   ScienceOn
13 Nakahara, H., Song, J., Sugimoto, M., Hagihara, K., Kishimoto, T., Yoshizaki, K., and Nishimoto, N., Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum. 48, 1521-1529 (2003).   DOI   ScienceOn
14 Nakajima, A., Azuma, M., Kodera, S., Nuriya, S., Terashi, A., Abe, M., Hirose, S., Shirai, T., Yagita, H., and Okumura, K., Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule. Eur. J. Immunol. 25, 3060-3069 (1995).   DOI   ScienceOn
15 Pollard, K.M., Arnush, M., Hultman, P., and Kono, D.H., Costimulation requirements of induced murine systemic autoimmune disease. J. Immunol. 173, 5880-5887 (2004).   DOI
16 Ciprandi, G., Murdaca, G., Colombo, B.M., De Amici, M., and Marseglia, G.L., Serum vascular endothelial growth factor in allergic rhinitis and systemic lupus erythematosus. Hum. Immunol. 69, 510-512 (2008).   DOI   ScienceOn
17 Fernandez, D., Bonilla, E., Phillips, P., and Perl, A., Signaling abnormalities in systemic lupus erythematosus as potential drug targets. Endocr. Metab. Immune. Disord. Drug Targets 6, 305-311 (2006).   DOI   ScienceOn
18 Haas, C., Ryffel, B., and Le Hir, M., IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupusprone (NZB x NZW)F1 mice. J. Immunol. 160, 3713-3718 (1998).
19 Hinson, R.M., Williams, J.A. and Shacter, E., Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2. Proc. Natl. Acad. Sci. U S A, 93, 4885-4890 (1996).   DOI   ScienceOn
20 Herrera-Acosta, J., Reyes, P.A., Lopez Manay, G., Padilla, L., Cerdas Calderon, M., Ruiz, A., and Perez Grovas, H., Inhibition of prostaglandin synthesis results in suppression of renal functional reserve in lupus nephritis. Rev. Invest. Clin. 39, 107-114 (1987).
21 Hoffman, R.W., T cells in the pathogenesis of systemic lupus erythematosus. Clin. Immunol. 113, 4-13 (2004).   DOI   ScienceOn
22 Kinoshita, K., Tesch, G., Schwarting, A., Maron, R., Sharpe, A.H., and Kelley, V.R., Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice. J. Immunol. 164, 6046-6056 (2000).   DOI
23 Akaogi, J., Nozaki, T., Satoh, M., and Yamada, H., Role of $PGE_2$ and EP receptors in the pathogenesis of rheumatoid arthritis and as a novel therapeutic strategy. Endocr. Metab. Immune. Disord. Drug Targets 6(4), 383-394 (2006).
24 Anderson, B.O. and Harken, A.H., Multiple organ failure: inflammatory priming and activation sequence promote autologous tissue injury. J. Trauma 30, S44-S49 (1990).
25 Aringer, M. and Smolen, J.S., SLE - Complex cytokine effects in a complex autoimmune disease: tumor necrosis factor in systemic lupus erythematosus. Arthritis Res. Ther. 5, 172-177 (2003).
26 Chae, B.S. and Park, B.H., Bamboo culm extract downregulated activation of NKT- and B- cells and production of IL-6 in pristaneinduced lupus mice. Natural Product Sciences 15(4), 222-228 (2009).   과학기술학회마을
27 Ballara, S., Taylor, P.C., Reusch, P., Marme, D., Feldmann, M., Maini, R. N., and Paleolog, E.M., Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis. Arthritis Rheum. 44, 2055-2064 (2001).   DOI   ScienceOn
28 Balomenos, D., Rumold, R., and Theofilopoulos, A.N., Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest. 101(2), 364-371 (1998).   DOI   ScienceOn
29 Betz, M. and Fox, B.S., Prostaglandin $E_2$ inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146, 108-113 (1991).
30 Chae, B.S. and Shin, T.Y., Immunoregulatory abnormalities of T cells and hyperreactivity of B cells in the in vitro immune response in pristaneinduced lupus mice. Arch. Pharm. Res. 30(2), 191-198 (2007).   과학기술학회마을   DOI   ScienceOn
31 Shacter, E., Arzadon, G.K., and Williams, J., Elevation of interleukin-6 in response to a chronic inflammatory stimulus in mice: inhibition by indomethacin. Blood 80, 194-202 (1992).
32 Yin, D., Zhang, L., Wang, R., Radvanyi, L., Haudenschild, C., Fang, Q., Kehry, M.R., and Shi, Y., Ligation of CD28 in vivo induces CD40 ligand expression and promotes B cell survival. J. Immunol. 163, 4328-4334 (1999).
33 Zhang, Y., Yao, X., Bao, B., and Zhang, Y., Anti-fatigue activity of a triterpenoid-rich extract from Chinese bamboo shavings (Caulis bamfusae in taeniam). Phytother. Res. 20, 872-876 (2006).   DOI   ScienceOn
34 Reininger, L., Santiago, M.L., Takahashi, S., Fossati, L., and Izui, S., T helper cell subsets in the pathogenesis of systemic lupus erythematosus. Ann. Med. Interne. (Paris) 147, 467-471 (1996).
35 Richards, H.B., Satoh, M., Shaw, M., Libert, C., Poli, V., and Reeves, W.H., Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristaneinduced lupus. J. Exp. Med. 188, 985-990 (1998).   DOI   ScienceOn
36 Seki, T., Kida, K. and Maeda, H., Immunostimulation-Mediated Antitumor Activity of Bamboo (Sasa senanensis) Leaf Extracts Obtained Under 'Vigorous' Condition. eCAM 7, 1-11 (2008).
37 Takeuchi, T., Tsuzaka, K., Abe, T., Yoshimoto, K., Shiraishi, K., Kameda, H., and Amano, K., T cell abnormalities in systemic lupus erythematosus. Autoimmunity 38, 339-346 (2005).   DOI   ScienceOn