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Screening of Protein Tyrosine Phosphatase 1B Inhibitory Activity from Some Vietnamese Medicinal Plants  

Hoang, Duc Manh (Research Institute of Obesity Science, and Dept. of Food and Nutrition, Sungshin Women's University)
Trung, Trinh Nam (College of Pharmacy, Chungnam National University)
Hien, Phan Thi Thu (Traditional Medicinal Departments, Ministry of Health)
Ha, Do Thi (College of Pharmacy, Chungnam National University)
Van Luong, Hoang (Vietnam Military Medical University)
Lee, Myoung-Sook (Research Institute of Obesity Science, and Dept. of Food and Nutrition, Sungshin Women's University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.16, no.4, 2010 , pp. 239-244 More about this Journal
Abstract
Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signaling, has served as a potential drug target for the treatment of type 2 diabetes. The MeOH extracts of twenty-nine medicinal plants, traditionally used in Vietnam as anti-diabetes agents, were investigated for PTP1B inhibitory activity in vitro. The results indicated that, most materials showed moderate to strong inhibitory activity with $IC_{50}$ values ranging from $3.4\;{\mu}g/mL$ to $35.1\;{\mu}g/mL$; meanwhile, eleven extracts (37.9%) could demonstrate PTP1B activity with $IC_{50}$ values less than $15.5\;{\mu}g/mL$; sixteen extracts (55.2%) could demonstrate PTP1B activity with $IC_{50}$ values ranging from $15.5\;{\mu}g/mL$ to $35.1\;{\mu}g/mL$. The study may provide a proof, at least in a part, for the ethno-medical use in diabetes disease of these plants.
Keywords
Vietnamese medicinal plants; Protein tyrosine phosphatase 1B (PTP1B); diabetes;
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