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DNA Topoisomerase I Inhibitory Activity of Stilbenes and Oligostilbenes from Leaf and Stem of Vitis amurensis  

Kang, Na-Na (College of Pharmacy, Chungnam National University)
Ha, Do Thi (College of Pharmacy, Chungnam National University)
Park, Chang-Sik (Research Center for Transgenic Cloned Pigs, Chungnam National University)
Myung, Pyung-Keun (College of Pharmacy, Chungnam National University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.16, no.4, 2010 , pp. 223-227 More about this Journal
Abstract
The DNA Topoisomerase I (DNA Topo I) inhibitory effect of ten isolated compounds (1.10) from the leaf and stem of Vitis amurensis were examined. Among them, amurensin G (5) and r-2-viniferin (7) showed high potent inhibitory activity against DNA Topo I. DNA Topo I, an important target for anticancer drugs, can cause DNA breaks and play a key role during cell proliferation, transcription and repair. Thus, the results suggest that the selected compounds (5 and 7) from Vitis amurensis have a possibility as DNA Topo I-targeting anticancer agents.
Keywords
Vitis amurensis; Stilbenes and Oligostilbenes; DNA Topo I;
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