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Anti-inflammatory Activity of Detoxified Bacterial Strains in Wistar Rats  

Sur, Tapas Kumar (Department of Pharmacology, Institute of Post Graduate Medical Education & Research)
Auddy, Biswajit (Department of Pharmacology, Institute of Post Graduate Medical Education & Research)
Mitra, Susil Kumar (Department of Pharmacology, Institute of Post Graduate Medical Education & Research)
Sarkar, Dipak Kumar (Department of Pharmacology, Institute of Post Graduate Medical Education & Research)
Bhattacharyya, Dipankar (Department of Pharmacology, Institute of Post Graduate Medical Education & Research)
Publication Information
Natural Product Sciences / v.16, no.3, 2010 , pp. 159-163 More about this Journal
Abstract
A mixture of several detoxified bacterial strains ($Sterodin^{(R)}$) has been studied for anti-inflammatory effect in Wistar rats on carrageenin, dextran and prostaglandin $E_1$ ($PGE_1$) induced edema in acute model and cotton pellet and carrageenin induced sub-acute model, while, Freund's adjuvant induced chronic model. The bacterial strains showed strong inhibitory activity in acute, sub-acute and chronic models of inflammation. Further, it reduced ${\alpha}1$ acid glycoprotein and ${\alpha}2$ macroglobulin levels in serum and prostaglandin $E_2$ in inflamed paw. These results indicated that the bacterial strains probably act through prostaglandin mediatory pathways and may be useful in treatment of inflammation.
Keywords
Bacteria; Inflammation; Prostaglandins; Freund's complete adjuvant; Glycoprotein; Macroglobulin;
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