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Microbial Metabolism of Yangonin, a Styryl Lactone from Piper methysticum (Kava)  

Kim, Ji-Hye (Marine Natural Products Chemistry Laboratory, Korea Ocean Research & Development Institute)
Kim, Hyun-Jung (Medical Research Center for Gene Regulation and the Brain Korea 21 Project, Chonnam National University Medical School)
Lee, Ik-Soo (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
Publication Information
Natural Product Sciences / v.16, no.3, 2010 , pp. 148-152 More about this Journal
Abstract
Microbial metabolism studies of yangonin (1), a major styryl lactone from Piper methysticum, have resulted in the production of three hydroxylated metabolites (2-4). The chemical structures of these compounds were elucidated to be 4-methoxy-6-(12-hydroxystyryl)-2-pyrone (2),4-methoxy-6-(11,12-dihydroxystyryl)-2-pyrone (3),and 4,12-dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone (4) on the basis of the chemical and spectroscopic analyses. The compounds 3 and 4 are reported herein as microbial metabolites of yangonin for the first time.
Keywords
Microbial metabolism; Yangonin; Styryl lactone; Piper methysticum; Kava;
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