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Cognitive Enhancing Activity of Betula platyphylla Sap in Scopolamine Induced Amnesic Mice  

Kim, Seung-Hyun (Institute for Life Science, Elcomscience Co. Ltd.)
Jeon, Byung-Ju (Institute for Life Science, Elcomscience Co. Ltd.)
Kim, Dae-Hyun (Institute for Life Science, Elcomscience Co. Ltd.)
Kim, Bo-Ram (Institute for Life Science, Elcomscience Co. Ltd.)
Lee, Ki-Yong (College of Pharmacy, Seoul National University)
Kim, Tae-Bum (College of Pharmacy, Seoul National University)
Park, Jung-Hyun (College of Pharmacy, Seoul National University)
Kim, Young-Choong (College of Pharmacy, Seoul National University)
Sung, Sang-Hyun (College of Pharmacy, Seoul National University)
Publication Information
Natural Product Sciences / v.16, no.1, 2010 , pp. 50-53 More about this Journal
Abstract
Cognitive enhancing activity of Betula plantyphylla sap was determined in scopolamine induced amnesic mice using passive avoidance test. Oral acute administration of the sap effectively reversed memory deficit in a dose dependent manner. Then the sap was standardized on the basis of sugar contents using HPLC combined with refractive index detector. Glucose and fructose were the main sugars present in the sap.
Keywords
Betula platyphylla sap; Cognitive-enhancing activity; Passive avoidance test;
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