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Screening of Vietnamese Medicinal Plants for Cytotoxic Activity  

Thu, Nguyen Bich (National Institute of Medicinal Materials)
Trung, Trinh Nam (College of Pharmacy, Chungnam National University)
Ha, Do Thi (National Institute of Medicinal Materials)
Khoi, Nguyen Minh (National Institute of Medicinal Materials)
Hung, Tran Viet (Department of Physics, National Institute of Control Quality and Quantity)
Hien, Tran Thi (Hanoi University of Pharmacy)
Yim, Nam-Hui (College of Pharmacy, Chungnam National University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.16, no.1, 2010 , pp. 43-49 More about this Journal
Abstract
Thirty-two methanol extracts of thirty-one Vietnamese medicinal plants were evaluated for the cytotoxic activity against five human cancer cell lines, including A549, MCF-7, HT 1080, Huh-7, and HepG2. Of these, the nine extracts of Acanthopanax trifoliatus (4), Acanthopanax gracilistylus (5), Siegesbeckia orientalis (10), Betula alnoides (11), Passiflora edulis (18), Zanthoxylum simulans (leaf, 23), Adenosma caeruleum (26), Solanum verbascifolium (29), and Alpinia malaccensis (31), exhibited high potent cytotoxic activity showing a certain degree of selectivity against the different cell types, with $IC_{50}$ values ranging from 2.1 to $3.8\;{\mu}g/mL$.
Keywords
Cytotoxicity; Vietnamese medicinal plants;
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