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Anti-oxidative Activities of Phenolic Compounds from barks of Pinus densiflora Siebold et Zuccarini  

Kwon, Joo-Hee (College of Pharmacy, Chung Ang University)
Kwon, Yong-Min (College of Pharmacy, Chung Ang University)
Choi, Sun-Eun (College of Pharmacy, Chung Ang University)
Park, Kwan-Hee (College of Pharmacy, Chung Ang University)
Lee, Min-Won (College of Pharmacy, Chung Ang University)
Publication Information
Natural Product Sciences / v.16, no.1, 2010 , pp. 10-14 More about this Journal
Abstract
Phytochemical examination of the barks of Pinus densiflora Siebold et Zuccarini has led to the isolation of one phenylpropanoid, one lignan, one flavonoid, one flavan 3-ol and two procyanidins : 4-O-$\beta$-D-glucopyranosyl-p-coumaric acid (1), 2,3-dihydro-2-(4-methoxy)-7-hydroxy-3-hydroxymethyl-5-(3-hydroxy propyl)-benzofuran 3-O-$\alpha$-D-glucopyranoside (2), taxifolin 3'-O-$\beta$-D-glucopyranoside (3), (+)-catechin (4), procyanidin B1 (5) and epicatechin-($4{\beta}$-8)-catechin-($4{\alpha}$-8)-catechin (6). Among them, Compound 4, 5 and 6 showed potent anti-oxidative activities and these anti-oxidative activities were significantly different compared with ascorbic acid as positive control.
Keywords
Pinus densiflora; antioxidative activity; lignan; flavonoid; procyanidin; DPPH;
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1 Packer, L., Rimbach, G., and Virgili, F., Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radical Biology and Medicine. 27, 704-724 (1999).   DOI   ScienceOn
2 Park, J.H., Kim, J.S., Jeong, A.Y., and Lee, J.D., Phytochemical study on the Vitis thunbergii var. sinuate. Korean J.Plant.Res. 9(1), 55-62 (1996).
3 Song, H.K. and Oh, S.J., Isolation and Structure Elucidation of Proanthocyanidin in Bark of Pinus densiflora. Mokchae Konghak. 24, 81-93 (1996).
4 Hatano, T., Edamatsu, R., Hiramatsu, M., Mori, A., Fujita, Y., Yasuhara, T., Yoshida, T., and Okuda, T., Effects of the interaction of tannins with co-existing substances. VI. Effects of tannins and ralated polyphenols on superoxide anion radical, and on 1,1-diphenyl-2- picrylhydrazyl radical. Chem. Pharm. Bull. 37, 2016 (1989).   DOI
5 Hsu, F., Nonaka, G., and Nishioka, I., Tannins and ralated compounds. XXXIII. Isolation and characterization of procyanidins in Dioscrea cirrhora LOUR. Chem. Pharm. Bull. 33, 3293-3298 (1985).   DOI
6 Ishimaru, K., Nonaka, G.I., and Nishioka, I., Gallic acid esters of protoquercitol, quinic acid and (-)-shikimic acid from Quercus mongolica and Quercus myrsin aefolia. Phytochemistry. 26, 1501-1504 (1987).   DOI   ScienceOn
7 Jung, M.J., Choi, J.H., Chung, H.Y., Jung, J.H., and Choi, J.S., A new Cmethyleted flavonoid glycoside from Pinus densiflora. Fitoterapia. 72, 943-945 (2001).   DOI   ScienceOn
8 Kim, H., Song, H.K., and Chung, D.K., Chemical analysis of Coniferous Flavonoids in Korea. The flavonoids of Red Pine Bark (Pinus densiflora). Mokchae Konghak. 19, 73-79 (1991).
9 Lee, M.W., Tanaka, T., Nonaka, G., and Hahn, D.R., Phenolic compounds on the leaves of Betula platyphylla var. latifolia. Arch. Pharm. Res. 15, 211-214 (1992).   DOI
10 Lee, S.K. and Bae, Y.S., Flavonoid acetylated glycosides of the Needles of Pinus densiflora, Mokchae Konghak. 29, 48-52 (2001).
11 Lundgren, L.N., Popoff, T., and Theander, O., Dilignol glycosides from needles of Picea abies. Phythochemistry. 20, 1967-1969 (1981).   DOI   ScienceOn
12 Miyase, T., Ueno, A., Takizawa. N., Kobayashi, H., and Oguchi, H., Ionone and lignin glycosides from Epimedium diphyllum. Phytochemistry. 28, 3483-3485 (1989).   DOI   ScienceOn
13 Erben, B., Benjamin, H., and Lau, S., Pycnogenol Inhibits generation of Inflammatory mediators in macrophage. Nutrition Research. 20, 249-259 (2000).   DOI   ScienceOn
14 Oleszek, W., Stochmal, A., Karolewski, P., Simonet, A., Macias, F., and Tava, Al., Flavonoids from Pinus sylvestris needles and their variation in trees of different origin grown for nearly a century at the same area. Biochemical Systematics and Ecology. 30, 1011-1022 (2002).   DOI   ScienceOn
15 Cho, K.J., Chang, H.Y., Yoon, D.Y., Cho, Y.S., Rimbach, G., Packer, L., and Chung, A.S., Effects of Bioflavonoids Extracted from the bark of Pinus maritima on Proinflammatory Cytokine Interlukin-1 Production in Lipopolysaccharide-Stimulated RAW 254.7. Toxicology and Applied Pharmacology. 168, 64-71 (2000).   DOI   ScienceOn
16 Choi, J.H., Kim, H.S., Jung, M.J., and Choi, J.S., (+) Catechin, and Antioxidant Principle from the Leaves of pinus densiflora that Acts on 1,1-diphenyl-2-picrylhydrazyl radical. Natural Product Sciences. 7, 1- 4 (2001).
17 Hans, A., Matthias, L., Reiner, W., Mahabir, G., and Pablo, S., New lignin glyxosides from Stemmadenia minima. Planta. Med. 58. 270-272 (1992).   DOI   ScienceOn
18 Fabio, V., Kobuchi, H., and Lester, P., Procyanidins Extracted From Pinus maritime (Pycnogenol) Scavengers of Free Radical Species and Modulators of Nitrogen Monoxide Metabolism in Activated Murine RAW 264.7 Macrophages. Free Radical Biology and Medicine. 24, 1120-1129 (1998).   DOI   ScienceOn