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Effects of ${\alpha}$-Asarone against Global Cerebral Ischemia in Rats  

Kim, Young-Ock (Herbal Crop Processing Research Team Department of Herbal Crop Research National Institute of Horticultural & Herbal Science Rural Development Administration)
Kwon, Yong-Soo (Department of Pharmacy, College of Pharmacy, Kangwon National University)
Lee, Seong-Eun (Herbal Crop Processing Research Team Department of Herbal Crop Research National Institute of Horticultural & Herbal Science Rural Development Administration)
Lee, Sang-Won (Herbal Crop Processing Research Team Department of Herbal Crop Research National Institute of Horticultural & Herbal Science Rural Development Administration)
Lee, Hee-Jae (Department of pharmacology, College of Medicine, Kangwon National University)
Publication Information
Natural Product Sciences / v.15, no.4, 2009 , pp. 198-202 More about this Journal
Abstract
Based on the use of Acorus gramineus SOLAND (AG) for the treatment of stroke in traditional Korean medicine, the present study was carried out to evaluate neuroprotective effects of ${\alpha}$-asarone after transient global cerebral ischemia using rat 4-vessel occlusion (4VO) model in rats. ${\alpha}$-Asarone (5 mg/kg) administered intraperitoneally significantly protected CA1 neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. ${\alpha}$-Asarone significantly reduced hippocampal neuronal cell death by 85.2% where as its isolated single compounds from AG compared with a vehicle-treated group.
Keywords
Stroke; Neuroprotective; ${\alpha}$-Asarone; Global cerebral ischemia;
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1 Cho, J., Kong J.Y., Jeong D.Y., Lee K.D., Lee D.U., and Kang B.S., NMDA receptor-mediated neuroprotection by essential oils from rhizomes of Acorus gramineus. Life Sci 68,1567-1573 (2001)   DOI   ScienceOn
2 Choi, D.W., Ischemia-induced neuronal apoptosis. Curr. Opin. Neurobiol. 6, 667-672 (1996)   DOI   PUBMED   ScienceOn
3 Ilhuicamina, D.Lim$\acute{o}$n., Liliana, M., Alfonso, D$\acute{i}$az., Germ$\acute{a}$nm,C., Blanca, E., and Edgar, Z., Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected with amyloid-$beta_{(25-35)}$35). Neurosci. Lett. 453, 98-103 (2009)   DOI   ScienceOn
4 Kirino, T., Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239, 57-69 (1982)   DOI   PUBMED   ScienceOn
5 Watanabe, H., Candidates for cognitive enhancer extracted from medicinal plants: Paeoniflorin and tetramethylpyrazine. Behav. Brain Res. 83, 135-141 (1997)   DOI   PUBMED   ScienceOn
6 Zeng, Y., and Xu, Z.C., Co-exsistence of necrosis and apoptosis in rat hippocampus following transient forebrain ischemia. Neurosci. Res. 237, 113-125 (2000)   DOI   ScienceOn
7 Pulsinelli, W.A., and Brierley, J.B., A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10, 871-877 (1979)
8 Chun, H.S., Kim, J.M., Choi, E.H., and Chang, N., Neuroprotective effects of several Korean medicinal plants traditionally used for stroke remedy. J. Med. Food 2, 246-251 (2008)   DOI
9 Barnes, C.A., Spatial learning and memory process: the search for their neurological mechanisms in the rats. Trends Neurosci. 11, 163-169 (1988)   DOI   PUBMED   ScienceOn
10 Colbounce, F., and Corben, D., Delayed and prolonged post-ischemic hypothermia is neuroprotection in the gerbil. Brain Res. 654, 265-272 (1994)   DOI   ScienceOn
11 Pulsinelli, W.A., Brierley, J.B., and Plum, F., Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11, 491-498 (1982)   DOI   ScienceOn
12 Ader, R, Wejnen, J.A.W.M., and Moleman, P., Retention of passive avoidance response as a function of the intensity and duration of electric shock. Psycon. Sci. 26, 125-128 (1972)
13 Cho, J., Joo, N.E., Kong, J.Y., Jeong, D.Y., Lee, K.D., and Kang, B. S., Inhibition of excitotoxic neuronal death by methanol extract of Acori graminei rhizoma in cultured rat cortical neurons. J Ethnopharmacol. 73, 31-37 (2000)   DOI   ScienceOn
14 Kirino, T. and Sano, K., Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol. 62, 201-208 (1984)   DOI   ScienceOn
15 Xuejiang, W., Magara, T., and Konishi, T., Prevention and repair of cerebral ischemia-reperfusion injury by Chinese herbal medicine, shengmai san, in rats. Free Radic. Res. 31, 449-455 (1999)   DOI   ScienceOn
16 Mori, K., Yoshioka, M., Suda, N., Togashi, H., Matsumoto, M., Ueno, K., and Saito, H., An incomplete cerebral ischemia produced a delayed dysfunction in the rat hippocampal system. Brain Res. 795, 21-226 (1998)   DOI   ScienceOn
17 Senda, T., Matsuno, K., Kobayashi, T., and Mita, S., Reduction of scopolamine induced impairment of passive avoidance performance by a- receptor agonist in mice. Physiol. Behav. 61, 257-264 (1997)   DOI   ScienceOn
18 Dandiya, P. C. and Cullumbine, H. Studies on Acorus calamus (III): Some pharmacological actions of the volatile oil. J. Pharmacol. Exp. Ther. 125, 353-359 (1959)   PUBMED   ScienceOn
19 Dandiya, P.C. and Sharma, J.D., Studies on Acorus calamus (V): Pharmacological action of asarone and $\beta$-asarone on central nervous system. Indian J. Med. Res. 50, 46-60 (1962)   PUBMED
20 Ginsberg, M.D. and Busto, R., Rodent models of cerebral ischemia. Stroke; 20, 1627-1642 (1989)   PUBMED   ScienceOn
21 Fibiger, H.C., Central cholinergic systems and memory. in Squire, L.R., Lindenlaub, E. (eds.), The Biology of Memory, Symposia Medica, Hoechst. New York' Springer-Verlag, 1990, pp. 35-47