Browse > Article

Anti-inflammatory Activity of Chrysanthemum indicum L. Extract in Lipopolysaccharide-treated Rats  

Lee, Eun (Department of Pharmaceutical Engineering, College of Health Sciences, Sangji University)
Publication Information
Natural Product Sciences / v.15, no.2, 2009 , pp. 55-59 More about this Journal
Abstract
This study for developing a new anti-inflammatory medicine was sought by investigating the antiinflammatory properties of C. indicum L. extract. Rats were treated with either saline (control) or C. indicum L. extract and then injected with LPS. We found that the plasma concentration of IL-1${\beta}$ IL-6, TNF-${\alpha}$and IL-10 peaked at 5h after LPS injection, and the plasma concentration of IL-6 and TNF-${\alpha}$ showed a tendency to decrease, and IL-10 concentration showed a tendency to increase with increasing levels of C. indicum L. extract. In the liver concentration of cytokines at 5 h post LPS injection, IL-1${\alpha}$ and IL-6 decreased with increasing concentration of C. indicum L. extract, however TNF-${\alpha}$ and IL-10 did not differ significantly the treatment groups.
Keywords
Chrysanthemum indicum L., Cytokines; Anti-inflammatory activity; Lipopolysaccharides;
Citations & Related Records

Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Harbrecht, B.G., Disilvio, M., Demetris, A.J., Simmons, R.L., and Billiar, T.R., Tumor necrosis factor-α regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia. Hepatology 20, 1055-1060 (1994)   DOI   ScienceOn
2 Hudson, L.D., Milberg, J.A., Anardi, D., and Maunder, R.J., Clinical risks for development of the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 15, 1293-1301 (1995)
3 Sang, H., Wallis, G.L., Stewart, C.A., and Kotake, Y., Expression of cytokines and activation of transcription factors in lipopolysaccharideadministered rats and their inhibition by phenyl N-tert-butylnitrone (PBN). Arch. Biochem. Biophys. 363, 341-348 (1999)   DOI   ScienceOn
4 Thompson, K.C., Trowern, A., Fowell, A., Marathe, M., Haycock, C., and Arthur, M.J.P., Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin-10 during the course of activation in vitro. Hepatology 28, 1518-1524 (1998)   DOI   ScienceOn
5 Simpson, K. J., Lukacs, N. W., Colletti, L., Strieter, R.M., and Kunkel, S.L., Cytokines and the liver. J. Hepatol. 27, 1120-1232 (1997)   DOI   ScienceOn
6 Gabay, C., and Kushner, I., Acute-phase proteins and other systemic responses to inflammation. N. Eng. J. Med. 340, 448-454 (1999)   DOI   ScienceOn
7 Aono, K., Isobe, K., Kuichi, K., Fan, Z., Ito, M., and Takeuchi, A., In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: involvement of other cytokines. J. Cell Biochem. 65, 349-358 (1997)   DOI   ScienceOn
8 Marriot, J.B., Westby, M., Cookson, S., Guckian, M., Goodbourn, S., and Muller, G., CC-3052: a water-soluble analog of thalidomide and potent inhibitor of activation-induced TNF-$\alpha$ production. J. Immunol. 161, 4236-4243 (1998)   PUBMED
9 Simoes, C.M., Schenkel, E.P., Baucer, L., and Langeloh, A., Pharmacological investigations on Archyrocline satureioides (LAM.) DC., Compositae. J. Ethnopharmacol. 22, 281-293 (1988)   DOI   ScienceOn
10 Mathiak, G., Grass, G., Herzmann, T., Luebke, T., Zetina, C.C., Boehm, S.A., Bohlen, H., Neville, L.F., and Hoelscher, A.H., Capase-1- inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br. J. Pharmacol. 131, 383-386 (2000)   DOI   ScienceOn
11 Moreira, A.L., Sampaio, E.P., Zmuidzinas, A., Frindt, P., Smith, K.A., and Kaplan, G., Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J. Exp. Med. 177, 1675-80 (1993)   DOI   PUBMED   ScienceOn
12 Barton, C.C., Barton, E.X., Ganey, P.E., Kunkel, S.L., and Roth, R.A., Bacterial lipopolysaccharide enhances aflatoxin $B_1$ hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor-$\alpha$ Hepatology 33, 66-73 (2001)   DOI   ScienceOn
13 Ryu, S.Y., Choi, S.U., Lee S.H., Ahn, J.W., and Zee, O.P., Antitumor activity of some phenonic components in plants. Arch. Pharm. Res. 17: 42-44, (1994)   DOI   ScienceOn
14 Cheng, W., Li, J., You, T., and Hu, C., Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linne,. J. Ethnopharmacol. 101, 334-337 (2005)   DOI   ScienceOn
15 Klapproth, J., Geiger, T., Andus, T., and Heirich, P.C., Fate and biological action of human recombinant interleukin 1$\beta$ in the rat in vivo. Eur. J. Immunol. 19, 1485-1490 (1980)   DOI   ScienceOn
16 Eduard, F.M., Martha, S.M. R., Victor, P.A., and Pablo, M., Immunomodulatory effects of thalidomide analogs on LPS-induced plasma and hepatic cytokines in the rat. Biochem. Pharmacol. 68, 1321-1329 (2004)   DOI   ScienceOn
17 Lee, D.Y., Choi, G.Y., Yoon, T.S., and Cheon, M.S., Anti-inflammatory activity of Chrysanthemum indicum extract in acute and chronic cutaneous inflammation. J. Ethnopharmacol. 123, 149-154 (2009)   DOI   ScienceOn
18 Chamulitrat, W., Blazka, M. E., Jordan, S.J., Luster, M.I., and Mason, R.P., Tumor necrosis factor-α and nitric oxide production in endotoxin-primed rats administered carbon tetrachloride. Life Sci 24, 2273-80 (1995)   DOI   ScienceOn
19 Chao, C.Y., Yeh, S.L., Lin, M.T., and Chen, W.J., Effects of parenteral infusion with fish-oil or safflower-oil emulsion on hepatic lipids, plasma amino acids, and inflammatory mediators in septic rats. Nutrition 16, 284-288 (2000)   DOI   ScienceOn
20 Louis, H., LeMoine, O., Peny, M.O., Quertinmont, E., Fokan, D., and Goldman, M., Production and role of interleukin-10 in concanavalin A- induced hepatitis in mice. Hepatology 25, 1382-1389 (1997)   DOI   ScienceOn
21 Belvisi, M.G., Brown,T.J., Wicks, S., and Foster, M.L., New glucocorticosteroids with an improved therapeutic ratio. Pulm. Pharmacol. Ther. 14, 221-227 (2001)   DOI   ScienceOn