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Protective Effect of Some Medicinal Plants on tert-Butyl Hydroperoxide-Induced Oxidative Stress in Human Keratinocytes  

Na, Min-Kyun (College of Pharmacy, Yeungnam University)
Jang, Tae-Su (Department of Wellbeing Therapy, Sorabol College)
Choi, Ji-Young (College of Pharmacy, Yeungnam University)
Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.14, no.4, 2008 , pp. 244-248 More about this Journal
Abstract
It is well known that excessive production of reactive oxygen species (ROS) leads to oxidative stress, loss of cell function, and ultimately apoptosis or necrosis. To search for natural antioxidants able to modulate cellular oxidative stress, we investigated the protective effect of ethanol extracts of 17 medicinal plants selected from the preliminary antioxidant screening on tert-butyl hydroperoxide (t-BuOOH)-induced oxidative stress in human keratinocytes. The result showed that extracts of the four plants, Distylium racemosum, Astilbe chinensis, Cercis chinensis and Sapium japonicum, exhibited significant cytoprotective activity (over 50% protection) against t-BuOOH-induced cellular injury.
Keywords
oxidative stress; antioxidants; medicinal plant extracts; tert-butyl hydroperoxide; cytoprotective activity; human keratinocytes;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By SCOPUS : 0
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