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Free Radical Scavengers from the Fruits of Paeonia suffruticosa  

Lee, Sa-Im (College of Pharmacy, Woosuk University)
Yang, Jae-Heon (College of Pharmacy, Woosuk University)
Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University)
Kim, Sung-Hoon (College of Oriental Medicine, KyungHee University)
Cho, Chong-Hyeon (Jeollabuk-do Agricultural Research and Extension Servieces)
Park, Byung-Hyun (Department of Biochemistry, Medical School, Chonbuk National University)
Chae, Byeong-Suk (College of Pharmacy, Woosuk University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Publication Information
Natural Product Sciences / v.14, no.3, 2008 , pp. 202-205 More about this Journal
Abstract
The antioxidant activity of Paeonia suffruticosa (Paeoniaceae) was determined by measuring the radical scavenging effect on DPPH (1,1-diphenyl-2-picrylhydrazyl). The methanolic extract of P. suffruticosa showed the strong antioxidant activity. The antioxidant activity of ethyl acetate soluble fraction was stronger than that of the others ($IC_{50}$, $1.2\;{\mu}g/mL$), and the fraction was subjected to purification by repeated silica gel and Sephadex LH-20 column chromatography. Suffruticosol A, suffruticosol B, methyl gallate, and gallic acid, were isolated from the ethyl acetate soluble fraction. Their structures were elucidated by physico-chemical and spectroscopic studies.
Keywords
Paeonia suffruticosa; antioxidant activity; methyl gallate; gallic acid; suffruticosol A; suffruticosol B; DPPH radical;
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