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Evaluation of the Hepatoprotective effect of Ephedra foliate, Alhagi maurorum, Capsella bursa-pastoris and Hibiscus sabdariffa Against Experimentally Induced Liver Injury in Rats  

Alqasoumi, Saleh I. (Department of Pharmacognosy, College of Pharmacy)
Al-Rehaily, Adnan J. (Department of Pharmacognosy, College of Pharmacy)
AlSheikh, Abdulmalik M. (Department of Pathology, College of Medicine, King Saud University)
Abdel-Kader, Maged S. (Department of Pharmacognosy, College of Pharmacy)
Publication Information
Natural Product Sciences / v.14, no.2, 2008 , pp. 95-99 More about this Journal
Abstract
In a project to study the hepatroprotective effect of some plant extracts four plants Ephedra foliate Boiss, Alhagi maurorum Medikus, Capsella bursa-pastoris (L.) Medik. and Hibiscus sabdariffa L. were studied. The ethanol extract of the aerial part of the first three plants and the flowers of H. sabdariffa were subjected to hepatoprotective assays using Wistar albino rats. Liver injury induced in rats using carbon tetrachloride. The biochemical parameters; serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin were estimated as reflection of the liver condition. Based on the good results of the biochemical parameters measurements, histopathological study was performed on the liver of rats treated with E. foliate. The normal appearance of hepatocytes indicated a good protection of the extract from carbon tetrachloride hepatotoxicity. All the results were compared with silymarin, the reference hepatoprotective drug.
Keywords
Ephedra foliate; Alhagi maurorum; Capsella bursa-pastoris; Hibiscus sabdariffa; carbon tetrachloride; hepatoprotection; silymarin; rats;
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