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Cytotoxic Compounds from the Stem Bark of Magnolia obovata  

Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu)
Youn, Ui-Joung (College of Pharmacy, Chungnam National University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.14, no.2, 2008 , pp. 90-94 More about this Journal
Abstract
Two sesquiterpenes (1 - 2), a tetralone (3), and two phenylpropanoids (4 - 5) were isolated from the stem bark of Magnolia obovata Thunberg (Magnoliaceae) through repeated column chromatography. Their structures were identified as ${\beta}-eudesmol$ (1), cryptomeridiol (2), 4R-4,8-dihydroxy-${\beta}-tetralone$ (3), trans-pcoumaryl aldehyde (4), and p-coumaric acid (5) on the basis of spectroscopic analysis including two dimensional NMR and mass. Compounds 1 - 3 were tested in vitro for their cytotoxic activity against the K562, HeLa, A549, and HCT116 cancer cell lines. However, compounds 1 - 3 were inactive in this assay system.
Keywords
Magnolia obovata; Magnoliaceae; sesquiterpene; tetralone; cytotoxic activity;
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