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Radical Scavenging Effects and Protective Effect of Spatholobus suberectus against $CCl_4-induced$ Liver Damage in Rats  

Jeon, Hoon (College of Pharmacy, Woosuk University)
Cha, Dong-Seok (College of Pharmacy, Woosuk University)
Ko, Sung-Hoon (College of Pharmacy, Woosuk University)
Park, Ho-Jun (College of Pharmacy, Woosuk University)
Lee, Yong-Jae (College of Pharmacy, Woosuk University)
Lee, Se-Youn (College of Pharmacy, Woosuk University)
Lim, Jong-Pil (College of Pharmacy, Woosuk University)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Oh, Chan-Ho (Department of Food Biotechnology, Woosuk University)
Eun, Jae-Soon (College of Pharmacy, Woosuk University)
Yang, Jae-Heon (College of Pharmacy, Woosuk University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Bu, Young-Min (College of Oriental medicine, Kyung Hee University)
Kim, Sung-Zoo (Department of Physiology, Chonbuk National University Medical School)
Publication Information
Natural Product Sciences / v.14, no.2, 2008 , pp. 127-130 More about this Journal
Abstract
In the present study, we obtained an extract from the dried stem of Spatholobus suberectus Dunn by using 85% methanol (MeOH extract of S. suberectus; MSS) and investigated its radical scavenging effects in vitro and its protective effect against $CCl_4-induced$ liver damage in rats. MSS scavenged the 1,1-diphenyl-2- picrylhydrazyl radical almost completely and inhibited $FeSO_4-induced$ lipid peroxidation (LPO) in the liver homogenate. Oral administration of MSS significantly reduced the serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and alkaline phosphatase and inhibited LPO in the liver tissue after $CCl_4$ treatment in rats. These results suggest that S. suberectus could be a candidate agent for the treatment of diseases related to oxidative stress.
Keywords
Spatholobus suberectus; carbon tetrachloride; free radical; lipid peroxidation; antioxidant effect;
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Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 1
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