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Antioxidant Activities of Phenolic Derivatives from Dipsacus asper Wall. (II)  

Hung, Tran Manh (College of Pharmacy, Chungnam National University)
Thuong, Phuong Thien (College of Pharmacy, Chungnam National University)
Youn, Ui-Joung (College of Pharmacy, Chungnam National University)
Zhang, Xin Feng (College of Forestry and Biotechnology, ZheJiang Forestry University)
Min, Byung-Sun (College of Pharmacy, Daegu Catholic University)
Woo, Mi-Hee (College of Pharmacy, Daegu Catholic University)
Lee, Hyeong-Kyu (Korea Research Institute of Science and Biotechnology)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.14, no.2, 2008 , pp. 107-112 More about this Journal
Abstract
The six phenolic compounds isolated from the root of Dipsacus asper, 3,4-di-O-caffeoylquinic acid (1), methyl 3,4-di-O-caffeoyl quinate (2), 3,5-di-O-caffeoylquinic acid (3), methyl 3,5-di-O-caffeoyl quinate (4), 4-5-di-O-caffeoylquinic acid (5), methyl 4,5-di-O-caffeoyl quinate (6) were continuously evaluated for their antioxidant activity using superoxide radical scavenging and AAPH-mediated (LDL) oxidation assay. The results demonstrated that compounds 1 - 6 had remarkable antioxidant activities with the $IC_50$ values ranging from 12.0 to $2.8{\mu}M$ in superoxide radical scavenging. They also inhibited AAPH-mediated low-density lipoprotein LDL oxidation by the generation of thiobarbituric acid reactive substances (TBARS) with $IC_50$ ranging from 6.7 to $8.7{\mu}M$.
Keywords
Dipsacus asper; Dipsacaceae; phenolic; superroxide radical scavenging; low-density lipoprotein;
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Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 3
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