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Inhibitory Effect of Astragaloside I and IV on Passive Cutaneous Anaphylaxis Reaction and Scratching Behaviors in Mice  

Han, Sang-Jun (College of Pharmacy, Kyung Hee University)
Bae, Eun-Ah (College of Pharmacy, Kyung Hee University)
Trinh, Hien Trung (College of Pharmacy, Kyung Hee University)
Yang, Jung-Hwa (College of Pharmacy, Kyung Hee University)
Lee, Eun-Ju (College of Pharmacy, Kyung Hee University)
Kang, Sam-Sik (College of Pharmacy, Kyung Hee University)
Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
Publication Information
Natural Product Sciences / v.14, no.1, 2008 , pp. 47-50 More about this Journal
Abstract
To evaluate the antiallergic effect of the dried root of Astragalus membranaceus Bunge (AM) (Leguminosae), which inhibited the mouse passive cutaneous anaphylaxis (PCA) reaction in a preliminary experiment, its main constituents, astragalosides I and IV, were isolated and their antiallergic effects were investigated. Astragalosides I and IV inhibited the PCA reaction induced by the IgE-antigen complex, and the scratching behaviors induced by compound 48/80. These constituents reduced the protein expressions of $TNF-{\alpha}$ and IL-4 in IgE-induced RBL-2H3 cells. These findings suggest that astragalosides I and IV as well as AM can improve IgE-induced anaphylaxis and scratching behaviors.
Keywords
Astragalus membranaceus; astragaloside; allergy; anaphylaxis; itching;
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