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Inhibitory Activity of IL-6 Production by Flavonoids and Phenolic Compounds from Geranium thunbergii  

Liu, Qing-He (College of Pharmacy, Chosun University)
Woo, Eun-Rhan (College of Pharmacy, Chosun University)
Publication Information
Natural Product Sciences / v.14, no.1, 2008 , pp. 16-20 More about this Journal
Abstract
Three flavonoids (1 - 3) and three phenolic compounds (4 - 6) were isolated from the whole plant of Geranium thunbergii Sieb. et Zucc (Geraniaceae). Their structures were determined by chemical and spectral analysis. These compounds were examined for the inhibitory activity of IL-6 production in $TNF-{\alpha}$ stimulated MG-63 cell. Among the isolated compounds, gallic acid (4) and gallic acid methyl ester (6) showed potent inhibitory activity.
Keywords
Geranium thunbergii Sieb. et Zucc.; Geraniaceae; gallic acid; IL-6 inhibitory activity;
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