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Cytoprotective Constituents of Alpinia katsumadai Seeds Against Glutamate-Induced Oxidative Injury in HT22 Cells  

Jeong, Gil-Saeng (Institute for Radiological Imaging Science, Wonkwang University)
Li, Bin (College of Pharmacy, Wonkwang University)
Lee, Dong-Sung (College of Pharmacy, Wonkwang University)
Byun, Erisa (College of Pharmacy, Wonkwang University)
Kang, Dae-Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Ho-Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
Publication Information
Natural Product Sciences / v.13, no.3, 2007 , pp. 268-271 More about this Journal
Abstract
Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as epilepsy and ischemia. Bioassay-guided fractionation of the MeOH extract of the seeds of Alpinia katsumadai Hayata (Zingiberaceae) furnished three phenolic compounds, alpinetin (1), pinocembrin (2), and (+)-catechin (3). Compounds 2 and 3 showed the potent neuroprotective effects on glutamate-induced neurotoxicity and reactive oxygen species (ROS) generation in the mouse hippocampal HT22 cells. In addition, Compounds 2 and 3 showed significant DPPH free radical scavenging effect. These results suggest that compounds 2 and 3 could be the effective candidates for the treatment of ROS-related neurological diseases.
Keywords
Glutamate-induced toxicity; Alpinia katsumadai; HT22; DPPH; Cytoprotective;
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