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12,13-Dihydroxyfumitremorgin C, Fumitremorgin C, and Brevianamide F, Antibacterial Diketopiperazine Alkaloids from the Marine-Derived Fungus Pseudallescheria sp.  

Zhang, Dahai (Department of Chemistry, Pukyong National University)
Noviendri, Dedi (Department of Chemistry, Pukyong National University)
Nursid, Muhammad (Department of Chemistry, Pukyong National University)
Yang, Xiu-Dong (Department of Chemistry, Pukyong National University)
Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
Publication Information
Natural Product Sciences / v.13, no.3, 2007 , pp. 251-254 More about this Journal
Abstract
Dioxopiperazine alkaloids, 12R,13S-dihydroxyfumitremorgin C (1), fumitremorgin C (2), and brevianamide F (3), were isolated from the marine-derived fungus Pseudallescheria, and the absolute stereostructures of compounds 1 - 3 were elucidated on the basis of chemical and physicochemical evidence. Compounds 1 - 3 showed an antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The MIC (minimum inhibitory concentration) values of compounds 1 - 3 were 125 ${\mu}g/mL$ for all strains.
Keywords
Marine-derived fungus; Pseudallescheria sp.; 12,13-dihydroxyfumitremorgin C; fumitremorgin C; brevianamide F; antibacterial activity;
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Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 3
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