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A New Sphingosine from a Marine Sponge Haliclona (Reniera) sp.  

Mansoor, Tayyab A. (College of Pharmacy, Pusan National University)
Park, Tae-Seong (College of Pharmacy, Pusan National University)
Luo, Xuan (College of Pharmacy, Pusan National University)
Hong, Jong-Ki (College of Pharmacy, Kyung Hee University)
Lee, Chong-O. (Korea Research Institute of Chemical Technology)
Jung, Jee-H. (College of Pharmacy, Pusan National University)
Publication Information
Natural Product Sciences / v.13, no.3, 2007 , pp. 247-250 More about this Journal
Abstract
A new sphingosine (1) was isolated from the MeOH extract of a marine sponge Haliclona (Reniera) sp. by bioactivity-guided fractionation. The 1D and 2D NMR, and MS spectroscopic analyses were used to establish the planar structure of 1. The stereochemistry of the compound was defined on the basis of modified Mosher's method, comparison of optical rotation and NMR data with those of the reported. Compound 1 was mildly cytotoxic to a panel of five human solid tumor cell lines.
Keywords
marine sponge; Haliclona (Reniera) sp.; sphingosine; sterols; lysoPC;
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1 Devijver, C., Salmoun, M., Daloze, D., Braekman, J.C., Weerdt, W.H.D., Kluijver, M.J.D., and Gomez, R., (2R,3R,7Z)-20-Aminotetradec-7- ene-1,3-diol, a new amino alcohol from the Caribbean sponge Haliclona vansoesti. J. Nat. Prod. 63, 978-980 (1985)   DOI   ScienceOn
2 Sheikh, Y.M. and Djerassi, C., Steroids from sponges. Tetrahedron. 30, 4095-4103 (1974)   DOI   ScienceOn
3 Rovirosa, J., Vasques, M.D.L.L., and San-Martin A., Chemotaxonomic considerations in relation to sponges of the genera Reniera and Haliclona. Biochem. Sys. Ecol. 18, 53-55 (1990)   DOI   ScienceOn
4 Luo, X., Li, F., Shinde, P.B., Hong, J., Lee, C., Im, K.S., and Jung, J.H., 26,27-Cyclosterols and other polyoxygenated sterols from a marine sponge Topsentia sp. J. Nat. Prod. 69, 1760-1768 (2006)   DOI   ScienceOn
5 Gulavita, N.K. and Scheuer, P.J., Two epimeric aliphatic amino alcohols from a sponge Xestospongia sp. J. Org. Chem. J. Org. Chem. 54, 366- 369 (1989)   DOI
6 Santalova, E.A., Makrieva, T.N., Gorshkova, I.A., Dmitrenok, A.S., Krasokhin, V.B., and Stonik, V.A., Sterols from six marine sponges. Biochem. Biochem. Sys. Ecol. 32, 153-167 (2004)   DOI   ScienceOn
7 Enders, D. and Müller-Hüwen, A., Asymmetric synthesis of 2-amino-1,3- diols and D-erythro-sphinganine. Eur. J. Org. Chem. 2004, 1732-1739 (2004)   DOI   ScienceOn
8 Zielinski, J., Milkova, T., Popov, S., Marekov, N., and Djerassi, C., Minor and trace sterols in marine invertebrates 34. Isolation and structure elucidation of 24-methyl-5$\alpha$-cholesta-7,9(11),24(28)-trien-3$\beta$-ol, the first naturally occurring ${\Delta}^{7,9(11)}$ unsaturated marine sterol. Steroids 39, 675-680 (1982)   DOI   ScienceOn
9 Mansoor, T.A., Hong, J., Lee, C., Sim, C.J., Son, B.W., and Jung, J.H., Renierasides, new cerebrosides from a marine sponge Haliclona (Reniera) sp. J. Nat. Prod. Submitted (2007)
10 Seldes, A.M., Rovirosa, J., San, M.A., and Gros, E.G., Sterols from the sponge Haliclona chilensis. Comp. Biochem. Phys. Part B: Biochem. Molec. Biology 81, 119-122 (1985)   DOI   ScienceOn
11 Mansoor, T.A., Bae, B.H., Hong, J., Lee C., Im, K.S., and Jung, J.H., New fatty acid derivatives from Homaxinella sp., a marine sponge. Lipids 40, 981-985 (2005)   DOI   ScienceOn
12 Li, S., Wilson, W.K., and Schroepfer, Jr. G.J., Chemical synthesis of Dribo- phytosphingosine-1-phosphate, a potential modulator of cellular processes. J. Lipid Res. 40, 117-125 (1999)   PUBMED
13 Elenkov, I., Popov, S., and Andreev, S., Sterols from two Black Sea sponges (Haliclona Sp.). Comp. Biochem. Phys. Part B: Biochem. Molec. Biology. 123, 357-360 (1999)   DOI   ScienceOn