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Nucleoside Constituents of the Egyptian Tunicate Eudistoma laysani  

Abou-Hussein, Dina R. (Department of Pharmacognosy, Faculty of Pharmacy, Cairo University)
Badr, Jihan M. (Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University)
Youssef, Diaa T.A. (Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University)
Publication Information
Natural Product Sciences / v.13, no.3, 2007 , pp. 229-233 More about this Journal
Abstract
Chemical investigation of the crude extract of the Egyptian marine tunicate Eudistoma laysani led to the isolation of a new nucleoside; 3-deazainosine and four known ones; inosine, 2'-deoxyuridine, adenosine and 2'-deoxyadenosine. Structural elucidation of the isolated compounds was based on intensive studies of their spectral data including 1D ($^{1}H$ and $^{13}C$) and 2D ($^{1}H-^{1}H$ COSY, HMQC, HMBC) NMR together with mass spectra. The antioxidant effects of the isolated compounds were determined using DPPH, where they exhibited significant activities.
Keywords
Tunicates; Eudistoma laysani; nucleosides; spectroscopic techniques; antioxidant activity;
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1 Buckley, S., Barsky, L., Weinberg, K., and Warburton, D., In vivo inosine protects alveolar epithelial type 2 cells against hyperoxia-induced DNA damage though MAP kinase signaling. Am. J. Physiol. Lung Cell Mol. Physiol. 288, 569-575 (2005)   DOI   ScienceOn
2 Makarieva, T.N., Dmitrenok, A.S., Dmitrenok, P.S., Grebnev, B.B., and Stonik, V.A., Pibocin B, the first N-O-methylenediole marine alkaloid, a metabolite from the Far- Eastern Ascidian Eudistoma species. J. Nat. Prod. 64, 1559-1561(2001)   DOI   ScienceOn
3 Schrier, D.J., Lesch, M.E., Wright, C.D., and Gilbertsen, R.B., The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats. J. Immunol. 145, 1874-1879 (1990)   PUBMED
4 Takamatsu, S., Hodges, T.W., Rajbhandari, I., Gerwick, W.H, Hamann, M.T. and Nagle, D.G., Marine natural products as novel antioxidant prototypes. J. Nat. Prod. 66, 605-608 (2003)   DOI   ScienceOn
5 Weber, J.F., Fuhrman, F.A., Fuhrman, G.J., and Mosher, H.S., Isolation of allantoin and adenosine from the marine sponge Tethya aurantia. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 70B, 799-801 (1981)
6 Van Wagoner, R.M., Jompa, J., Tahir, A., and Ireland, C.M., Trypargine alkaloids from a Previously un-described Eudistoma sp. Ascidian. J. Nat. Prod. 62, 794-797 (1999)   DOI   ScienceOn
7 Agrawal, P.K., Carbon 13 NMR of flavonoids. Central Ins. of medicinal and aromatic plants, Luknow, India, Elsevier (1989)
8 Lidgren, G. and Bohlin, L., Studies of the Swedish marine organisms, Part X. Biologically active compounds from the marine sponge Geodia baretti. J. Nat. Prod. 51, 1277-1280 (1988)   DOI
9 Schupp, P., Peohner, T., Edrada, R. A., Ebel, R., Berg, A., Wray, V., and Proksch, P., Eudistomins W and X, two new $\beta$-carbolines from the micronesian tunicate Eudistoma sp. J. Nat. Prod. 66, 272-275 (2003)   DOI   ScienceOn
10 Schupp, P., Eder, C., Proksch, P., Wray, V., Schneider, B., Herderich, M., Paul, V., Staurosporine derivatives from the Ascidian Eudistoma toealensis and Predatory Flatworm Pseudoceros sp. J. Nat. Prod. 62, 959-962 (1999)   DOI   ScienceOn
11 Adesanya, S.A., Chbani, M., and Pais, M., Brominated $\beta$-carbolines from the marine tunicate Eudistoma album. J. Nat. Prod. 55, 525-527 (1992)   DOI
12 Schupp, P., Proksch, P., and Wray, V., Furthernew Staurosporine derivatives from the Ascidian Eudistoma toealensis and its Predatory Flatworm Pseudoceros sp. J. Nat. Prod. 65, 295-298 (2002)   DOI   ScienceOn
13 Campbell. I.L. and Taylor, K.W., A species difference in nucleoside phosphorylase activity and inosine-stimulated insulin secretion in isolated islets of Langerhans. Biochem. J. 168, 591-593 (1977)   DOI   PUBMED
14 Zhou, S., Zhou, K., and Xiao, D., Natural nitrogenous compounds from South China Sea marine sponge Clathria fasciculate. Zhongguo Haiyang Yaowu, 24, 31-35 (2005)
15 Paul, T. and Pfammatter, J.P., Adenosine: an effective and safe antiarrhythmic drug in pediatrics. Pediatr. Cardiol. 18, 118-126 (1997)   DOI   ScienceOn
16 Rashid, M.A. Gustafson, K.R., and Boyd, M.R., New cytotoxic Nmethylated $\beta$-carboline alkaloids from the marine Ascidian Eudistoma gilboverde. J. Nat. Prod. 64, 1454-1456 (2001)   DOI   ScienceOn
17 Gudkov, S.V., Shtarkman, I.N., Smirnova, V.S., Chernikov, A.I., Guanosine and inosine display antioxidant activity, protect DNA in vitro from oxidative damage induced by reactive oxygen species, and serve as radioprotectors in mice. Radiat. Res. 165, 538-545 (2006)   DOI   ScienceOn
18 Hou, B., You, S. W., Wu, M. M., Kuang, F., Liu, H.L., Jiao, X. Y., and Ju, G., Neuroprotective effect of inosine on axotomized retinal ganglion cells in adult rats. Invest. Ophthalmol. Vis. Sci. 45, 662-667 (2004)   DOI   ScienceOn
19 Jiao, Y., Valente, E., Garner, S.T., Wang, X., and Yu, H., Unexpected thermal rearrangement of N-alkoxycarbonylimidazoleacryl azides to imidazo[1,5-c]pyrimidinone or imidazo[4,5-c] pyridinone. Tetrahedron Lett. 43, 5879-5881 (2002)   DOI   ScienceOn
20 Ouyang, M., Liu, R., and Kuo, Y., A new cerebroside, Asperiamide A, from the marine fungus Aspergillus sp. J. Asian. Nat. Prod. Res. 7, 761-765 (2005)   DOI   ScienceOn
21 Campbell. I.L. and Taylor, K.W., Effects of adenosine, 2'-deoxyadenosine and N6-phenylisopropyladenosine on rat islet function and metabolism. Biochem J. 204, 689-696 (1982)   DOI   PUBMED
22 Aitken, R.J., Mattei, A., and Irvine, S., Paradoxical stimulation of human sperm motility by 2'-deoxyadenosine. J. Reprod. Fertil. 78, 515-527 (1986)   DOI   ScienceOn