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Effect of Dichrostachys cinerea (Linn.) Root Extract on Ethylene Glycol Induced Urolithiasis in Rats  

Rao, G. Srinivasa (Department of Pharmacognosy Vel's College of Pharmacy)
Jayakumari, S. (Department of Pharmacognosy Vel's College of Pharmacy)
Publication Information
Natural Product Sciences / v.13, no.3, 2007 , pp. 180-185 More about this Journal
Abstract
Dichrostachys cinerea (Linn.) is commonly known as Vadatalla and used as phytotherapeutic agent. Tender shoots of the plant bruised and applied to the eyes in case of ophthalmia. The root is astringent and used in rheumatism, urinary calculi and renal troubles. The effect of the Ethanolic and aqueous extract of the root of D. cinerea were studied for its anti-urolithiatic and diuretic activity at 200 mg/kg dose level in male Wistar albino rats. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Supplementation with aqueous and ethanolic extract of the plant significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. Compared to ethanolic extract, aqueous extract exhibited significant anti-urolithiatic activity. Both the extracts showed significant diuretic activity. The results of our present study supports folklore claim of D. cinerea.
Keywords
Dichrostachys cinerea; Urolithiasis; Ethylene glycol; Diuretic activity;
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