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Inhibitory Effect of Brassica rapa in Ovalbumin-Stimulated Experimental Asthmic Mice  

Bae, Eun-Ah (College of Pharmacy, Kyung Hee University)
Min, Seung-Won (College of Pharmacy, Kyung Hee University)
Kim, Nam-Jae (Korea Herbal Research Institute, Kyung Hee University)
Bang, Myung-Ho (Graduate School of Biotechnology and PMRC, Kyung Hee University)
Baek, Nam-In (Graduate School of Biotechnology and PMRC, Kyung Hee University)
Han, Eun-Joo (Ganghwa Agricultural R&D Center)
Chung, Hae-Gon (Ganghwa Agricultural R&D Center)
Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
Publication Information
Natural Product Sciences / v.13, no.2, 2007 , pp. 114-117 More about this Journal
Abstract
To evaluate antiallergic effect of Brassica rapa Metzg (BR, Family Cruciferae), which is widely used as a food source, its anti-asthmic effect was investigated. BR reduced IgE level in the blood of ovalbumin (OVA)-induced asthmic mice. BR also inhibited IgE and ploinflammatory cytokine IL-6 productions in trachea of OVA-induced mice, but did not inhibit IL-4 production. BR did not inhibit mRNA expression of proinflammatory cytokines IL-6 and IL-4 in IgE-induced RBL-2H3 cells. BR and its isolated components 10-undecenoic acid 2-methoxy methyl ester and galactosyl diglyceride potently inhibited the NO production of RAW264.7cells induced by lipopolysaccharide. These findings suggest that the anti-asthmic effect of BR may be due to the inhibition of the biosynthesis of proinflarnmatory cytokine IL-6 in macrophage and BR can improve IgE-induced allergic disease asthma.
Keywords
Brassica rapa; asthma; IgE; inflammation;
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