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Polyketides from a Sponge-Derived Fungus, Aspergillus versicolor  

Lee, Yoon-Mi (College of Pharmacy, Pusan National University)
Mansoor, Tayyab A. (College of Pharmacy, Pusan National University)
Hong, Jong-Ki (College of Pharmacy, Kyung Hee University)
Lee, Chong-O (Korea Research Institute of Chemical Technology)
Bae, Kyung-Sook (Korea Research Institute of Bioscience and Biotechnology)
Jung, Jee-H (College of Pharmacy, Pusan National University)
Publication Information
Natural Product Sciences / v.13, no.1, 2007 , pp. 90-96 More about this Journal
Abstract
Bioactivity guided fractionation of the cultured filtrates of Aspergillus versicolor, which was derived from a marine sponge Petrosia sp., yielded three polyketides: decumbenones A (1),B (2), and versiol (3). These compounds were identified on the basis of 1D and 2D NMR spectroscopic and MS analysis. The absolute configuration was defined by the modified Mosher's method. The isolated compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and antibacterial activity against twenty clinically isolated methicillin-resistant strains. This is the first report on the isolation of these compounds from a marine source.
Keywords
sponge-derived fungi; Aspergillus versicolor; polyketide; decumbenones A and B; versiol; Petrosia sp.;
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