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Antioxidant Constituents from Leonurus japonicus  

Qu, Guan-Zheng (School of Biotechnology, Kangwon National University)
Si, Chuan-Ling (Tianjin Key Laboratory of Pulp & Paper, Tianjin University of Science & Technology)
Wang, Myeong-Hyeon (School of Biotechnology, Kangwon National University)
Publication Information
Natural Product Sciences / v.12, no.4, 2006 , pp. 197-200 More about this Journal
Abstract
Two phenolic acids, gallic acid (1) and syringic acid (2), and five flavonoids, apigenin (3), luteolin (4), kaempferol (5), quercetin (6), and myricetin (7), were isolated from the aerial parts of Leonurus japonicus. Their structures were elucidated by chemical and spectral analysis. The antioxidant activities of the crude extracts, partitioned fractions and isolated compounds were evaluated by DDPH free radical-scavenging assay. Results suggested that the EtOAc partitioned fraction and compounds 1, 4, 5, 6, and 7 showed significantly high antioxidant potential compared with $\alpha-tocopherol$ and BHT, which were used as controls.
Keywords
Aerial parts; antioxidant; constituents; Leonurus japonicus;
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1 Chen, H., Huo, Y., Tan, D.X., Liang, Z., Zhang, W., and Zhang, Y., Melatonin in Chinese medicinal herbs. Life Sci. 73, 19-26 (2003)   DOI   ScienceOn
2 Chinwala, M.G., Gao, M., Oai, J., and Shao, J., In vitro anticancer activities of Leonurus heterophyllus Sweet (Chinese motherwort herb). J. Chinese Med. Mat. 25, 71-72 (2002)
3 Cong, Y., Wang, J.X., Guo, H.R., and Li, X., Isolation and identitication of the chemical constituents of Leonurus japonicus Houtt. II. Chinese J. Med. Chem. 13, 349-352 (2003)
4 Hamburger, M. and Hostetman, K., Bioactivity in plants: the link between phytochemistry and medicine. Phytochemistry 30, 3864-3884 (1991)   DOI   ScienceOn
5 Hotta, K., Noguchi, Y., Matsunaga, M., Nishibe, K., Uchida, K., Shimizu, K., Tetsuya, K., and Akinobu, S., Leonurus heterophyllus extracts and ${\beta}$-sitosterone as antiarrhythmics. Jpn. Kokai. Tokkyo Koho, 2003
6 Kashiwada, Y., Nonaka, G., and Nishoka, I., Galloylsucroses from Rhubarbs. Phytochemistry 27, 1469-1472 (1988)   DOI   ScienceOn
7 Saijo, R., Nonaka, G.I., and Nishioka, I., Gallic acid esters of bergen in and norbergenin from Mallotus japonicus. Phytochemistry 29, 267-270 (1990)   DOI   ScienceOn
8 Sherwin, E.R., Antioxidant, in Branen, A.L., Davidson, P.M., and Salminin, S. (Eds), Food. additives, New York, 1990
9 Weisburger, J.H., Hara, Y., Sulan, L., Luo, F.Q., Pittman, B., and Zang, E., Tea polyphenols as inhibitors of mutigenicity of major classes carcinogens. Mutat. Res. 371, 57-63 (1996)   DOI   ScienceOn
10 Yoshida, T., Mori, K., Hatano, T., Okumura, T., Uehara, I., Komagoe, K., Fujita, Y., and Okuda, T., Study on inhibition mechanism of autooxidation by tannins and flavonoids. V. Radical scavenging effects of tannins and related polyphenols on 1,1-diphenyl-2-picrylhydrazyl radical. Chem. Pharm. Bull. 37, 1919-1921 (1989)   DOI
11 Roman, R., Romero-Gonzalez, Jorge, L., Avila-Nunez, Lianne, A., Miguel, E., and Alonso-Amelot, Labdane diterpenes trom Leonurus japonicus leaves. Phytochemistry 67, 965-970 (2006)   DOI   ScienceOn
12 Okuyama, T., Hosoyama, K., Hiragam, Y., Kurono, G., and Takemoto, T., The constituents of Osmunda spp.: A new flavonol glycoside of Osmunda asiatica. Chem. Pharm. Bull. 26, 3071-3074 (1978)   DOI
13 The Wiley Registry of Mass Spectral Data, sixth Ed. Wiley, New York, 1996
14 Agrawal, P.K., Carbon-13 NMR of flavanoids. Elsevier, 1989
15 Sakushima, A.M., Cosakun, S.H., and Nishibe, S., Flavonoids from Rhamnus pallasii. Phytochemistry 22, 1677-1678 (1983)   DOI   ScienceOn
16 Wenkert, E. and Gottlieb, H.E., Carbon-13 nuclear magnetic resonance spectroscopy of flavonoid and isoflavonoid compounds. Phytochemistry 16, 1811-1816 (1977)   DOI   ScienceOn
17 Satoh, M., Satoh, Y., Isobe, K., and Fujimoto, Y., Studies on the constituents of Leonurus sibiricus L. Chem. Pharm. Bull. 52, 341-342 (2003)
18 Akdemir, A.S., Tati, I.I., Saraccoglu, I., Ismailoglu, U.B., Sahin-Erdemli, I., and Dalis, I., Polyphenolic compounds from Geranium pratense and their free radical scavenging activities. Phytochemistry 56, 189-193 (2001)   DOI   ScienceOn
19 Markham, K.R. and Chari, V.M., Carbon-13 NMR spectroscopy of flavonoids, in Harboren J.B., and Mabry T. (Eds.), The Flavonoids: Advances in research, Chapman and Hall Ltd., London, UK, 1982
20 Ternai, B. and Markham, K.R., Carbon-13 NMR studies of flavonoids-I: flavones and flavonols. Tetrahedron 32, 565-569 (1976)   DOI   ScienceOn
21 Pietta, P.G., Flavonoids as antioxidants. J. Nat. Prod. 63, 1035-1042 (2000)   DOI   ScienceOn
22 Giang, P.M., Son, P.T., Matsunami, K., and Otsuka, H., New bissirolabdane-type diterpenoids from Leonurus heterophyllus Sw. Chem. Pharm. Bull. 53, 1475-1479 (2005)   DOI   ScienceOn
23 Sugaya, K., Hashimoto, F., Ono, M., Ito, Y., Masuoka, C., and Nohara, T., Antioxidative constituents trom Leonurii Herba (Leonurus japonicus). Food Sci. Technol. Int. Tokyo 4, 278-281 (1998)   DOI
24 Wanasundara, U.N. and Shahidi, F., Antioxidant and prooxidant activity of green tea extracts in maine oils. Food Chem. 63, 335-342 (1998)   DOI   ScienceOn
25 De Souza, C., Haas, A.P., Von Poser, G.L., Schapobal, E.E., and Elisabetsky, E., Ethnoparmacological studies of antimicrobial remedies in the south of Brazil. J. Ethnopharmacol. 90, 135-143 (2004)   DOI   ScienceOn
26 Lee, C.M., Jiang, L.M., Shang, H.S., Hon, P.M., He, Y., and Womg, H.N., Prehispanolone, a novel platelet-activating factor receptor antagonist from Leonurus heterophyllus. Br. J. Pharmacal. 103, 1719-1724 (1991)   DOI   ScienceOn
27 Widy-Tyszkiewicz, E. and Schminda, R., A randomized double blind study of sedative effects of phytoterapeutic containing valerian, hops, balm, and motherwort versus placebo. Herba. Pol. 43, 154-159 (1997)
28 Markham, K.R., Ternai, B., Stanly, R., Geiger, H., and Mabry, T.J., Carbon-13 NMR studies of flavonoids-III: Naturally occurring flavonoid glycosides and their acetylated derivatives. Tetrahedron 34, 1389-1397 (1978)   DOI   ScienceOn
29 Ruan, J.L., Du, J.R., Zeng, Q.Z., and Qian, Z.M., Advance in studies on chemical components, harmacological effect and clinical application of Leonurus japonicus. Chinese Traditional and Herbal Drugs 34, 15-18 (2003)
30 Watanabe, M., Antioxidant phenolic compounds from Japanese barnyard millet (echinochloa utilis) grains. J. Agric. Food Chem. 47, 500-4505 (1999)