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Screening of Momordica dioica for Hepatoprotective, Antioxidant, and Antiinflammatory Activities  

Shreedhara, C.S. (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences)
Vaidya, V.P. (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences)
Publication Information
Natural Product Sciences / v.12, no.3, 2006 , pp. 157-161 More about this Journal
Abstract
The alcoholic extract of Momordica dioica roots significantly reduced $CCl_4$ induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transminases (SGPT), and alkaline phosphatase (ALP)]. These results were comparable with sylimarin (1.25 mg/kg, p.o.). The alcoholic extract inhibited the formation of oxyten derived free radicals (ODFR) in vitro with $4000\;{\mu}g/ml$ ascorbic system. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) and the activity was comparable with ibuprofen(200 mg/kg, p.o.).
Keywords
Momordica dioica; hepatoprotective activity; antioxidant activity; antiinflammatory activity; plethysmometer; carrageenan;
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