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Antiulcer Activity of Sida acuta Burm.  

Malairajan, P. (C. L. Baid Metha College of Pharmacy)
Gopalakrishnan, Geetha (Schering Plough Link, Singapore Ranch)
Narasimhan, S. (Asthagiri Herbal Research foundation, Tambaram Sanatorium)
Veni, K. Jessi Kala (S. R. M. College of Pharmacy, Kattankulathur)
Publication Information
Natural Product Sciences / v.12, no.3, 2006 , pp. 150-152 More about this Journal
Abstract
The ethanol extract of Sida acuta Burm. (ALSA) whole plant was studied for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer, HCl-ethanol induced ulcer, and water immersion stress induced ulcer (WISIU) in rats. We found that ALSA at a dose of 300 mg/kg, (orally) markedly decrease the incidence of ulcers in the first two models. ALSA showed reduction in gastric volume, free acidity, and ulcer index (53.69%). It has not reduced the total acidity significantly and no significant change in pH. It also showed 55.14% gastro protective activity, wheres standard drug sucralfate showed 94.85%. WISIU showed protection index 24.4%, whereas standard drug omeprazole (OMEZ) showed protection index 100%.
Keywords
antiulcer; Sida acuta; aspirin plus pylorous ligation ulceration; HCl-ethanol ulceration; water immersion stress ulcer;
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