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Antioxidant Activities of Vietnamese Medicinal Plants  

Thuong, Phuong Thien (College of Pharmacy, Chungnam National University)
Na, Min-Kyun (Korea Research Institute of Bioscience and Biotechnology)
Dang, Nguyen Hai (College of Pharmacy, Chungnam National University)
Hung, Tran Manh (College of Pharmacy, Chungnam National University)
Ky, Pham Thanh (Hanoi College of Pharmacy)
Thanh, Tran Van (Hanoi College of Pharmacy)
Nam, Nguyen Hai (Hanoi College of Pharmacy)
Thuan, Nguyen Duy (National Institute of Medicinal Materials)
Sok, Dai-Eun (College of Pharmacy, Chungnam National University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.12, no.1, 2006 , pp. 29-37 More about this Journal
Abstract
One hundred and twenty six Vietnamese traditional herbals belonging to 59 families were screened for their free radical (DPPH) scavenging activity and inhibitory effect on lipid peroxidation. Of these, MeOH extracts of seven plants, including Euphorbia thymifolia (leaf), Gnetum montanum (stem), Heterosmilax erythrantha (root), Morus alba (leaf), Syzygium formosum (leaf), Jussiaea repens (aerial parts), and Camellia sinensis (leaf), exhibited significant antioxidant activities. All of these herbs showed remarkable free radical scavenging activities with $IC_{50}$ values of 11.0, 14.5, 17.0, 13.6, 10.8, 7.7, and $8.5\;{\mu}g/ml$, respectively, and significant inhibitory effects on lipid peroxidation with 79.7, 83.8, 78.9, 82.5, 88.8, 88.0, and 96.2% inhibitions, respectively, at the concentration of $50\;{\mu}g/ml$.
Keywords
Vietnamese medicinal plants; antioxidant activity; free radical scavenging; lipid peroxidation;
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Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 6
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1 Banerjee, A., Dasgupta, N., and De, B., In vitro study of antioxidant activity of Syzygium cumini fruit. Food Chem. 90, 727-733 (2005)   DOI   ScienceOn
2 Kuo, Y.H., Chen, C.F., Kuo, L.M.Y., King, M.L., Chen, C.F., and Lee, K.H., Celahinine A, a new sesquiterpene pyridine alkaloid from Celastrus hindsii. J. Nat. Prod. 58, 1735-1738 (1995)   DOI
3 Nam, N.H., Kim, H.M., Bae, K.H., and Ahn, B.Z., Inhibitory effects of Vietnamese medicinal plants on tube-like formation of human umbilical venous cells. Phytother. Res. 17, 107-111 (2003)   DOI   ScienceOn
4 Nam, N.H., Kim, Y., You, Y.J., Hong, D.H., Kim, H.M., and Ahn, B.Z., New constituents from Crinum latifolium with inhibitory effects against tube-like formation of human umbilical venous endothelial cells. Nat. Prod. Res. 18, 485-491 (2004)   DOI   ScienceOn
5 Nam, N.H., Lee, C.W., Hong, D.H., Kim, H.M., Bae, K.H., and Ahn, B.Z., Antiinvasive, antiangiogenic and antitumour activity of Ephedra sinica extract. Phytother. Res. 17, 70-76 (2003)   DOI   ScienceOn
6 Pietta, P.G., 2000. Flavonoids as antioxidants. J. Nat. Prod. 63, 1035-1042   DOI   ScienceOn
7 Nonaka, G., Miwa, N., and Nishioka, I., Tannins and related compounds. Part 2. Stilbene glycoside gallates and proanthocyanidins from Polygonum multiflorum. Phytochemistry 21, 429-432 (1982)   DOI   ScienceOn
8 Ho, P.H., 1997. Vietnamese Flora. Science and Technology Publishing House, Hanoi, Vietnam
9 Yen, G.C., Wu, S.C., and Dub, P.D., Extraction and identification of antioxidant components from the leaves of Mulberry (Morus alba L.). J. Agr. Food Chem. 44, 1687-1690 (1996)   DOI   ScienceOn
10 Doi, K., Kojima, T., Makino, M., Kimura, Y., and Fujimoto, Y., Studies on the constituents of the leaves of Morns alba L. Chem. Pharm. Bull. 49, 151-153 (2001)   DOI   ScienceOn
11 Chen, Y., Wang, M.F., Rosen, R.T., and Ho, C.T., 2,2-Diphenyl-lpicrylhydrazyl radical-scavenging active components from Polygonum multiflorum Thunb. J. Agr. Food Chem. 47, 2226-2228 (1999)   DOI   ScienceOn
12 You, Y.J., Nam, N.H., Kim, Y., Bae, K.H., and Ahn, B.Z., Antiangiogenic activity of lupeol from Bombax ceiba. Phytother. Res. 17, 341-344 (2003)   DOI   ScienceOn
13 Wu, L., Smythe, A.M., Stinson, S.P., Mullendore, L.A., Monks, A., Scudiero, D.A., Paull, K.D., Koutsoukos, A.D., Rubinstein, L.V., Boyd, M.R., and Shoemaker, R.H., Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening. Cancer Res. 52, 3029-3034 (1992)
14 Nam, N.H., Cytotoxic principle of Siegesbeckia orientalis growing in Vietnam. Tap Chi Hoa Hoc 38, 84-86 (2000)
15 Nguyen, T.N.T, Kamenarska, Z., Bankova, V.. Popov, S., Zvetkova, E., Katzarovo, E., and Le, M.H., Cytotoxic activities of alkaloid fractions from Crinum latifolium L., Amaryllidaceae. Tap Chi Duoc Hoc 11, 21-23 (2001)
16 Huang, H.C., Shen, C.C., Chen, C.F., Wu, Y.C., and Kuo, Y.H., A novel agarofuran sesquiterpene, celahin D from Celastrus hindsii Benth. Chem. Pharm. Bull. 48, 1079-1080 (2000)   DOI   ScienceOn
17 Simonian, N.A., and Coyle, J.T., Oxidative stress in neurodegenerative diseases. Ann. rev. Pharmacol. Toxicol. 36, 83-106 (1996)   DOI   ScienceOn
18 Yen, G.C., and Hsieh, C.L, Antioxidant activity of extracts from Du-zhong (Eucommia ulmoides) toward various lipid peroxidation models in vitro. J. Agr. Food Chem. 46, 3952-3957 (1998)   DOI   ScienceOn
19 Ueda, J.Y., Tezuka, Y., Banskota, A.H., Tran, Q.L., Tran, Q.K, Harimaya, Y., Saiki, I., and Kadota, S., Antiproliferative activity of Vietnamese medicinal plants. Biol. Pharm. Bull. 25, 753-760 (2002)   DOI   ScienceOn
20 Kimura, Y., Ohminami, H., Okuda, H., Baba, K., Kozawa, M., and Arichi, S., Effects of stilbene components of roots of Polygonum ssp. on liver injury in peroxidized oil-fed rats. Planta Med. 49, 51-54 (1983)   DOI   ScienceOn
21 Yao, C.S., Zhou, L.X., and Lin, M., Preparation on oligostilbenes of isorhapontigenin by oxidative coupling reaction. Chem. Pharm. Bull. 52, 238-243 (2004)   DOI   ScienceOn
22 Halliwell, B., Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 344, 721-724 (1994)   DOI   ScienceOn
23 Brenner, A.J. and Harris, E.D., A quantitative test for copper using bicinchoninic acid. Anal. Biochem. 226, 80-84 (1995)   DOI   ScienceOn
24 Ham, A.J.L. and Liebler, D.C., Vitamin E oxidation in rat liver mitochondria. Biochemistry 34, 5754-5761 (1995)   DOI   ScienceOn
25 Lee, S.H., Tanaka, T., Nonaka, G., and Nishioka, I., Hydrolyzable tannins from Euphorbia thymifolia. Phytochemistry 29, 3621-3625 (1990)   DOI   ScienceOn
26 Kim, S. Y., Gao, J.J., Lee, W.C., Ryu, K.S., Lee, K.R., and Kim, Y.C., Antioxidative flavonoids from the leaves of Morns alba. Arch. Pharm. Res. 22, 81-85 (1999)   DOI   ScienceOn
27 Kohen, R., and Nyska, A., Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol. Pathol. 30, 620-650 (2002)   DOI
28 Lin, C.C., Cheng, H.Y, Yang, C.M., and Lin, T.C., Antioxidant and antiviral activities of Euphorbia thymifolia L. J. Biomed. Sci. 9, 656-664 (2002)
29 Li, X.M., Lin, M., Wang, Y.H., and Liu, X., Four new stilbenoids from the lianas of Gnetum montanum f. megalocarpum. Planta Med. 70, 160-165 (2004)   DOI   ScienceOn
30 Phan, T.S., Tran, B.D., Phan, M.G., Nguyen, T.M., Hoang, T.H., and Le, M.H., Investigation of antimicrobial and cytotoxic properties of alkaloids from some species of Crinum in Vietnam. Tap Chi Duoc Hoc 4, 18-21 (2003)
31 Kuo, Y.H., and Kuo, L.M.Y., Antitumor and anti-aids triterpenes from Celastrus hindsii. Phytochemistry 44, 1275-1281 (1997)   DOI   ScienceOn
32 Ryu, G.S., Ju, J.H., Park, Y.J., Ryu, S.Y., Choi, B.W., and Lee, B.H., The radical scavenging effects of stilbene glucosides from Polygonum multiflorum. Arch. Pharm. Res. 25, 636-639 (2002)   DOI   ScienceOn
33 Waddington, R.J., Moseley, R., and Embery, G., Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases. Oral Dis. 6, 138-151 (2000)   DOI   ScienceOn
34 Lee, K.G, and Shibamoto, T., Antioxidant property of aroma extract isolated from clove buds (Syzygium aromaticum). Food Chem. 74, 443-448 (2001)   DOI   ScienceOn
35 Xiang, W., Jiang, B., Li, X.M., Zhang, H.J., Zhao, Q.S., Li, S.H., and Sun, H.D., Constituents of Gnetum montanum. Fitoterapia 73, 40-42 (2002)   DOI   ScienceOn
36 Loi, D.T., Vietnamese medicinal plants and ingredients. Medical Publishing House, Hanoi, Vietnam (2001)
37 Na, M.K., An, R.B., Jin, W.Y., Min, B.S., Yoo, J.K., Kim, Y.H., and Bae, K.H., Antioxidant effects of plant extracts on free radicals and lipid peroxidation. Nat. Prod. Sci. 9, 226-231 (2003)
38 Chi, V.V., Dictionary of Vietnamese medicinal plants. Medical Publishing House, Hanoi, Vietnam (1997)
39 Halliwell, B., Aeschbach, R., Loliger, J., and Aruoma, O.I., The characterization of antioxidants. Food Chem. Toxicol. 33, 601-617 (1995)   DOI   ScienceOn
40 Nguyen, M.T.T., Awale, S., Tezuka, Y., Tran, Q.L., Watanabe, H., and Kadota, S., Xanthine oxidase inhibitory activity of Vietnamese medicinal plants. Biol. Pharm. Bull. 27, 1414-1421 (2004)   DOI   ScienceOn