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Protective Activity against Ionizing Radiation of Antioxidative Plants Indigenous to Korea  

Jung, Myung-Sun (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Kang, Kyoung-Ah (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Zhang, Rui (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Chae, Sung-Wook (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Yoo, Byoung-Sam (Cosmetic R&D Center, COSMAX Inc.)
Yang, Young-Taek (Jeju-do Agricultural Research & Extension Services)
Lee, Nam-Ho (Department of Chemistry, College of Natural Sciences, Cheju National University)
Park, Jae-Woo (Department of Nuclear and Energy Engineering, Cheju National University)
Hyun, Jin-Won (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Publication Information
Natural Product Sciences / v.12, no.1, 2006 , pp. 1-7 More about this Journal
Abstract
We have screened the cytoprotective effect on ${\gamma}-ray$ radiation induced oxidative stress from forty one Korean plant extracts. Carpinus laxiflora (caulis), Quercus salicina (caulis), and Castanopsis cuspidata (caulis) were found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). As a result, extracts of three plants reduced cell death of Chinese hamster lung fibroblast (V79-4) cells induced by $H_2O_2$ treatment. In addition, these extracts protected cell death of V79-4 cells damaged by ${\gamma}-ray$ radiation. In addition, these extracts scavenged ROS generated by radiation. Taken together, the results suggest that Carpinus laxiflora, Quercus salicina, and Castanopsis cuspidata protect V79-4 cells against oxidative damage by radiation through scavenging ROS.
Keywords
${\gamma}-ray$ radiation; oxidative stress; reactive oxygen species;
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