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Structure-Activity Relationship of Xanthones from Mesua daphnifolia and Garcinia nitida towards Human Estrogen Receptor Nagative Breast Cancer Cell Line  

Ee, G.C.L. (Department of Chemistry, Faculty of Science, Universiti Putra Malaysia)
Lim, C.K. (Department of Chemistry, Faculty of Science, Universiti Putra Malaysia)
Rahmat, A. (Department of Nutrition and Health Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia)
Publication Information
Natural Product Sciences / v.11, no.4, 2005 , pp. 220-224 More about this Journal
Abstract
Extensive chemical studies on the stem bark extracts of two Guttifereous plants namely Mesua daphnifolia and Garcinia nitida have led to the isolation of eight xanthones. Mesua daphnifolia gave cudraxanthone G (1), ananixanthone (2), 1,3,5-trihydroxy-4-methoxyxanthone (3) and euxanthone (4) while Garcinia nitida gave inophyllin B (5), 1,3,7-trihydroxy-2,4-bis (3-methylbut-2-enyl)xanthone (6), 3-isomangostin (7) and rubraxanthone (8). All these compounds were assayed against the MDA-MB-231 (human estrogen receptor negative breast cancer) cells. A structure-activity relationship study showed that structurally, all the 1, 3-oxygenated xanthones which carried unsaturated prenyl side chains (either 3-methylbut-2-enyl or 1,1-dimethyl-2-propenyl) at carbones C-2 and C-4 in the xanthone ring A are essential for the outstanding activities in the assay.
Keywords
Xanthones; Mesua daphnifolia; Garcinia nitida; Cytotoxic activities; MDA-MB-231;
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Times Cited By SCOPUS : 4
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