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Neuroprotective Effect of Acanthopanax sessiliflorus against Toxicity Induced by N-Methyl-D-Aspartate in Rat Organotypic Hippocampal Slice Culture  

Lee, Pyeong-Jae (Department of Agricultural Biology, National Institute of Agricultural Science and Technology)
Lee, Sang-Hyun (Department of Applied Plant Science, College of Industrial Science, Chung-Ang University)
Choi, Sang-Yoon (Korea Food Research Institute)
Son, Dong-Wook (KT&G Central Research Institute)
Publication Information
Natural Product Sciences / v.11, no.3, 2005 , pp. 179-182 More about this Journal
Abstract
We investigated that water extract of Acanthopanax sessiliflorus roots rescued the N-methyl-D-aspartate (NMDA), agonist of glutamate receptor, -induced toxicity in rat organotypic hippocampal slice culture. When the cell death in NMDA only-treated hippocampal slices was set 100%, A. sessiliflorus decreased the cell death to 75.4, 51.6, 48.9, and 40.6% at 1, 10, 50, and $100\;{\mu}g/ml$ treatment, respectively. On the basis of these results, the water extract of A. sessiliflorus roots may be a preventive agent against NMDA-induced cytotoxicity.
Keywords
Acanthopanax sessiliflorus; Araliaceae; N-Methyl-D-Aspartate; Exicitoxicity; Hippocampal slice culture; Neuroprotection;
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Times Cited By KSCI : 2  (Citation Analysis)
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