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The Chemical Constituents and their Antioxidant Activity of the Stem of Rhododendron mucronulatum  

Lee, Jin-Hoon (College of Pharmacy, Kangwon National University)
Jeon, Wan-Joo (Department of Pharmacology, College of Medicine, Kangwon National University)
Yoo, Eun-Sook (Department of Pharmacology, College of Medicine, Cheju National University)
Kim, Chang-Min (College of Pharmacy, Kangwon National University)
Kwon, Yong-Soo (College of Pharmacy, Kangwon National University)
Publication Information
Natural Product Sciences / v.11, no.2, 2005 , pp. 97-102 More about this Journal
Abstract
From the n-BuOH soluble traction of the 70% aqueous acetone extract of Rhododendron mucronulatum stem, twelve compounds were isolated. On the basis of spectral data, they were identified as scopoletin (1), (+)-taxifolin (2), quercetin (3), (-)-catechin (4), (+)-epicatechin (5), scopolin (6), lyoniside (7), ssioriside (8), fraxin (9), $(+)-lyoniresinol-3{\alpha}-O-{\beta}-D-glucopyranoside$ (10), $(+)-taxifolin-3-O-{\alpha}-L-arabinopyranoside$ (11), and astragalin (12), respectively. All isolated compounds were tested antioxidant activity against 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical. Compounds 2 and 3 showed the potent antioxidant activity, and compounds 5, 8, and 11 showed moderate activity.
Keywords
Rhododendron mucronulatum; Ericaceae; flavonoids; lignans; coumarins; antioxidant activity;
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1 Hwang, B.Y., Kim, H., Lee, J.H., Hong, Y.S., Rho, J.S., and Lee, J.J., Antioxidant benzoylated flavan-3-ol glycoside from Celastrus orbiculus. J. Nat. Prod., 64, 82-84 (2001)   DOI   ScienceOn
2 Lim, R.J., Flora Medica Coreana, Agriculture Publishing House, Pyongyang, p. 59 (1998)
3 Sakushima, A., and Nishibe, S., Taxifolin 3-arabinoside from Trachelospermum jasminoides var, pubescens. Phytochemistry, 27, 948-950 (1988)   DOI   ScienceOn
4 Steck, W. and Mazurek, M., Identification of natural coumarins by NMR spectroscopy. Lloydia, 35, 418-439 (1972)   PUBMED
5 Kuroyanagi, M., Shiotsu, M., Ebihara, T., Kawai, H., Ueno, A., and Fukushima, S., Chemical studies on Viburnum awabuki K. Koch. Chem. Phram. Bull., 34, 4012-4017 (1986)   DOI
6 Dada, G., Corbani, A., Manitto, P., Speranza, G., and Lunazzi, G., Lignan glycosides from the heartwood of European oak Quercus petraea. J. Nat. Prod., 52, 1327-1330 (1989)   DOI
7 Agrawal, P.K., Carbon-13 NMR of Flavonoids. Elsevier, 1989
8 Inoshiri, S., Sasaki, M., Kohda, H., Otsuka, H., and Yamasaki, K., Aromatic glycosides from Berchemia racemosa. Phytochemistry, 26, 2811-2814 (1987)   DOI   ScienceOn
9 Mabry, T.J., Markham, K.R., and Thomas, M.B., The Systematic Identification of Falvonoids, Springer-Verlag, 1970
10 Yoshinari, K., Sashida, Y., and Shimomura, H., Two new lignan xylosides from the barks of Prunus ssiori and Prunus padus. Chem. Pharm. Bull., 37, 3301-3303 (1989)   DOI
11 Min, B.S., Lee, J.P., Na, M.K., An, R.B., Lee, S.M., Lee, H.K., Bae, K.H., and Kang, S.S., A new naphthopyrone from the root of Pleuropterus ciliinervis. Chem. Pharm. Bull., 51, 1322-1324 (2003)   DOI   ScienceOn
12 Morimoto, S., Nonaka, G.I., Nishioka, I., Ezaki, N., and Takizawa, N., Tannins and related compounds. X X IX. Seven new methyl derivatives of flavn-3-ols and a 1,3-diarylpropan-2-ol from Cinnamonum cassia, C. obtusiflium and Lindera umbellata var. membranacea. Chem. Pharm. Bull., 33, 2281-2286 (1985)   DOI
13 Nonaka, G.I., Goto, Y., Kinjo, J.E., Nohara, T., and Nishioka, I., Tannins and related compounds. L II. Studies on the constituents of the leaves of Thujopsis dolabrata SIEB. et ZUCC., Chem. Pharm. Bull., 35, 1105-1108 (1987)   DOI
14 Chung, T.Y., Kim, M.A., and Jones, A.D., Antioxidative activity of flavonoids isolated from Jindalrae flowers (Rhododendron mucronulatum). Agric. Chem. Biotechnol., 39, 320-326 (1996a)
15 Chung, T.Y., Kim, M.A., and Jones, A.D., Antioxidative activity of phenolic acids isolated from Jindalrae flower (Rhododendron mucronulatum). Agric. Chem. Biotechnol., 39, 506-511 (1996b)
16 Murakami, T., Wada, H., Tanaka, N., Kido, T., Iida, H., Saiki, Y. and Chen, C.M., Chemical and chemotaxanomical studies of Filices. L X V. A new flavonoid glycosides. (2). Yakugaku Zasshi, 106, 982-988 (1986)   DOI
17 Kwon, Y.S. and Kim, C.M., A study on the chemical constituents from leaves of Fraxinus rhynchophylla. Kor. J. Pharmacogn., 27, 347-349 (1996)
18 Ishimaru, K., Omoto, T., Asai, I., Ezaki, K., and Shimomura, K., Taxifolin 3-arabinoside from Fragaria ananassa. Phytochemistry, 40, 345-347 (1995)   DOI   ScienceOn
19 Shibuya, H., Takeda, Y., Zhang, R.S., Tanitame, A., Tsai, Y.L., and Kitagawa, I., Indonesian medicinal plants. IV. On the constituents of the bark of Fagara rhetza (Rutaceae). (2). Lignan glycosides and two apioglucsides. Chem. Pharm. Bull., 40, 2639-2646 (1992)   DOI
20 Jin W.Y., Na, M.K., An, R.B., Lee, H.Y., Bae, K.H., and Kang, S.S., Antioxidant compounds from twig of Morus alba. Nat. Prod. Sci., 8, 129-132 (2002)
21 Nanjing University of TCM (edited), Chinese Herb Encyclopedia (Zhonghua Bencao), vol. 6, Shanghai Science & Technology Press, Shanghai, pp. 20-45 (1999)
22 Ohashi, K., Watanabe, H., Okumura, Y., Uji, T., and Kitagawa, I., Indonesian medicinal plants. X II Four isomeric lignan-glucosides from the bark of Aegle marmelos (Rutaceae). Chem. Pharm. Bull., 42, 1924-1926 (1994)   DOI
23 Lee, T.B., Illustrated Flora of Korea, Hynagmoonsa, Seoul, pp. 598-601 (1985)