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Honokiol : A Noncompetitive Tyrosinase Inhibitor from Magnoliae Cortex  

Tian, Yu-Hua (Phytofermentation Research Center and College of Pharmacy, Wonkwang University)
Kang, Tai-Hyun (Phytofermentation Research Center and College of Pharmacy, Wonkwang University)
Kim, Hyun-Chul (Phytofermentation Research Center and College of Pharmacy, Wonkwang University)
Kim, Youn-Chul (Phytofermentation Research Center and College of Pharmacy, Wonkwang University)
Publication Information
Natural Product Sciences / v.11, no.2, 2005 , pp. 89-91 More about this Journal
Abstract
Effect of the neolignans, honokiol (1) and magnolol (2), isolated from Magnoliae Cortex on mushroom tyrosinase activity was investigated in vitro using L-tyrosine as a substrate. Honokiol (1) inhibited tyrosinase activity significantly in a concentration-dependent manner, on the other hand, magnolol (2) did not show tyrosinase inhibitory effect. Honokiol exhibited tyrosinase inhibitory effect with $IC_{50}$ value of $67.9\;{\mu}M$, and proved to act as a non-competitive inhibitor by the analysis of Lineweaver-Burk plot.
Keywords
Honokiol; Tyrosinase inhibitor; Magnoliae Cortex;
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Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 0
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