Browse > Article

Anti-oxidative Phenolic Compounds from Sophorae Fructus  

Kim, Hyun-Jung (College of Pharmacy, Chung Ang University)
Kim, Min-Kee (College of Pharmacy, Chung Ang University)
Shim, Jae-Gul (College of Pharmacy, Chung Ang University)
Yeom, Seung-Hwan (College of Pharmacy, Chung Ang University)
Kwon, Suk-Hyung (College of Pharmacy, Chung Ang University)
Lee, Min-Won (College of Pharmacy, Chung Ang University)
Publication Information
Natural Product Sciences / v.10, no.6, 2004 , pp. 330-334 More about this Journal
Abstract
Four isoflavonoids and three flavonoids, and a gallotannin were isolated from the fruits of Sophora japonica (Leguminosae). Their structures were identified as genistein (1), sophoricoside (2), genistein-4'-O--L-rhamnopyranoside (3), $genistein-4 (4), $kaempferol-3-O-{\alpha}-D-sophoroside$ (5), $kaempferol-3-O-{\beta}-D-glucopyranosyl-(1{\rightarrow}2)-{\alpha}-L-rhamnopyranosly-(1{\rightarrow}6)-{\beta}-D-glucopyranoside$ (6), rutin (7) and gallic acid $4-O-{\beta}-D-(6 (8) by chemical and spectroscopic analysis and comparisons with previously reported spectral data. Compounds 3 and 8 were isolated for the first time from this plant. Anti-oxidative activity was evaluated for the isolated compounds. 8 exhibited potent anti-oxidative activity against the radical scavenging ability of DPPH with the $IC_{50}$ value of $17.1\;{\mu}g/ml$.
Keywords
Sophorae Fructus; isoflavonoids; flavonoids; gallotannin; antioxidative activity; DPPH;
Citations & Related Records

Times Cited By SCOPUS : 6
연도 인용수 순위
1 Harbome, J.B., and Mabry, T.J., The Flavonoids. Chapman and Hall, pp. 105 (1982)
2 Lee, YA., Cho, S.M., and Lee, M.W., Flavonoids from the Roots of Rhodiola sachalinensis. Kor. J. Phannacogn. 33: 116-119 (2002)
3 Lewis P.T., and Wahala K., Regiospecific 4-O--glucosidation of isoflavones. Tetrahedron Letters., 39, 9559-9562 (1998)   DOI   ScienceOn
4 Nonaka, G., and Nishioka I., Tannins and Related Compounds. X. Rhubarb (2) : Isolation and structures of a glycerol gallate, gallic acid glucoside gallates, galloylgiucoses and isolindleyin. Chem. Pham. Bull. 31:1652-1658 (1983)   DOI
5 Jeffrey, B., Harbome, F.R.S., and Herbert, B., The Handbooks of Natural Flavonoids. Vol 2. pp. 671 (1999)
6 Djerrassi, C., Dictionary of Natural Products. Vol 5. Chapman and Hall, pp. 5471 and 5796 (1994)
7 Agrawal, P.K., Carbon-13 NMR of flavonoids. Elsevier. pp. 347 (1989)
8 Harbome, J.B., and Mabry, T.J., The Flavonoids. Chapman and Hall, pp. 105 (1982)
9 Wenzel, D., Kuntz, S., Brendel, M.D., and Daniel, H., Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. Cancer Res., 60, 3823-3831 (2000)
10 Kim, T.W., The Woody Plants of Korea in Color., Kyo-Hak Publishing Co., Seoul, Korea. pp. 399 (1995)
11 Michael, E.E., Manual of cultivated broad-leaved trees & shrubs. Volume, Timber Press, Protland, Oregon. pp. 325-327 (1986)
12 Nature, and Medicin study association of Korea, Life-Chinese Medicine' FolkMedicine. DongBu-MunHwaSa. pp. 21 (1985)
13 Park, Y.K., Lee, H.J., Choi, D.H., Kwon, Y.H., and Oh, J.S., Extractives from the Bark of Sophora japonica L. Mokchae Konghak. 30: 42-47 (2002)
14 Saxena, Y.K., and Madhuri Singai, Genistein 4'-O-$\alpha$-L-rhamno pyranoside from Pithecellobium dulce. Fitoterapia. 69: 305-306 (1998)
15 Takeda, T., Ishiguro, I., Masegi, M., and Ogihara, Y., New isoflavone glycosides from the woods of Sophora japonica. Phytochemistry. 16: 619-620 (1997)   DOI   ScienceOn
16 Kim, Y.R., Isolation of rutin from Amaranthus mangotanus. Kor. J. Pharmacogn. 31: 249-251 (2000)
17 Shirataki, Y., Takaya, Y., Yokoe, I., and Komatsu, M., Soporaside A, A new aromatic glycoside from the roots of Sophora japonica. Chern, Pharm. Bull. 35: 1637-1640 (1987)   DOI