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Antiallergic and Anti-asthmatic Activities of the Alcoholic Extract of Terminalia arjuna and Arjunolic Acid  

Prasad, M.V.V. (Department of Pharmaceutical Chemistry, Dr. HCT College of Pharmacy)
Anbalagan, N. (Department of Pharmaceutical Chemistry, C. L. Baid Metha College of Pharmacy)
Patra, A. (Department of Chemistry, University College of Science)
Veluchamy, G. (Central Research Institute for Siddha)
Balakrishna, K. (Central Research Institute for Siddha)
Publication Information
Natural Product Sciences / v.10, no.5, 2004 , pp. 240-243 More about this Journal
Abstract
In the present study, the alcoholic extract of Terminalia arjuna (TA) and Arjunolic acid (AA) were studied fur its anti-asthmatic and anaphylactic activity. Treatment with TA (250 & 500 mg/kg) and AA (50 & 100 mg/kg) has shown significant protection against mast cell disruption in rats induced by compound 48/80. TA and AA also protected the guinea pig against histamine as well as acetylcholine induced bronchospasm. Both TA & AA exhibited better protection against histamine release than against acetylcholine release. Anti-asthmatic and anaphylactic activity may be possibly due to membrane stabilizing potential and inhibition of antigen induced histamine and acetylcholine release.
Keywords
Anti-asthmatic; anti-histaminic; terminalia arjuna; arjunolic acid;
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