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Inhibition of L-DOPA-Induced Increase in Dopamine Content by $(1R,9S)-{\beta}-Hydrastine$ Hydrochloride in PC12 cells  

Yin, Shou-Yu (College of Pharmacy, Yanbian University)
Lee, Jae-Joon (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University)
Kim, Yu-Mi (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University)
Jin, Chun-Mei (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University)
Yang, Yoo-Jung (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University)
Kang, Min-Hee (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University)
Lee, Myung-Koo (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University)
Publication Information
Natural Product Sciences / v.10, no.3, 2004 , pp. 119-123 More about this Journal
Abstract
The effects of BHSH on L-DOPA-induced increase in dopamine content in PC12 cells were investigated. L-DOPA treatment at $20\;or\;50\;{\mu}M$ increased dopamine content after both 24 and 48 h of incubation in PC12 cells. However, the co-treatments of BHSH $(10-50\;{\mu}M)$ with L-DOPA $(20\;or\;50\;{\mu}M)$ significantly inhibited the increase of dopamine content induced by L-DOPA. BHSH treatment at $10-50\;{\mu}M$ significantly inhibited basal aromatic L-amino acid decarboxylase (AADC) activity in a concentration-dependent manner at 15 min, and then AADC activity was rapidly recovered to the control level at about 2 h. These results indicate that the inhibition of AADC activity by BHSH was, in part, contributed to the early-stage decrease of dopamine content induced by LDOPA in PC12 cells. Taken together, it is proposed that the short-term inhibition of dopamine biosynthesis by BHSH was mediated by the regulation of tyrosine hydroxylace (TH).
Keywords
$(1R,9S)-{\beta}-Hydrastine$ hydrochloride; L-DOPA; Tyrosine hydroxylase; Aromatic L-amino acid decarboxylase; PC12 cells;
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