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Chemical Constituents and Biological Activities of Cichorium intybus L.  

El-Lakany, Abdalla M. (Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria)
Aboul-Ela, Maha A. (Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria)
Abdul-Ghani, Mohamed M. (Department of Organic Chemistry, Faculty of Science, Beirut Arab University)
Mekky, Hattem (Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria)
Publication Information
Natural Product Sciences / v.10, no.2, 2004 , pp. 69-73 More about this Journal
Abstract
Continuation of a phytochemical study of Cichorium intybus L. (Astraceae) growing in Egypt, resulted in the isolation and identification of a new sesquiterpene lactone 3,4-dihydrolactucin, in addition to the eight known compounds; kaempferol, isoscutellarin, cichoriin, umbelliferone, lupeol, lupeol acetate, ${\beta}-sitosterol$, and ${\beta}-sitosterol-3-O-glucoside$. Chemical structures of the isolated compounds were assigned based on different physical, chemical, and spectroscopic techniques including IR, UV, MS, 1D- and 2D-NMR spectra. Furthermore, the antimicrobial, and spasmogenic activities of some fractions and isolates were also assessed.
Keywords
Cichorium intybus L.; Lactuaceae; Asteraceae; chemical constituents; new sesquiterpene lactone; antimicrobial; spasmogenic activities;
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