Browse > Article

Chemical Constituents and Biological Activities of Cichorium intybus L.  

El-Lakany, Abdalla M. (Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria)
Aboul-Ela, Maha A. (Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria)
Abdul-Ghani, Mohamed M. (Department of Organic Chemistry, Faculty of Science, Beirut Arab University)
Mekky, Hattem (Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria)
Publication Information
Natural Product Sciences / v.10, no.2, 2004 , pp. 69-73 More about this Journal
Abstract
Continuation of a phytochemical study of Cichorium intybus L. (Astraceae) growing in Egypt, resulted in the isolation and identification of a new sesquiterpene lactone 3,4-dihydrolactucin, in addition to the eight known compounds; kaempferol, isoscutellarin, cichoriin, umbelliferone, lupeol, lupeol acetate, ${\beta}-sitosterol$, and ${\beta}-sitosterol-3-O-glucoside$. Chemical structures of the isolated compounds were assigned based on different physical, chemical, and spectroscopic techniques including IR, UV, MS, 1D- and 2D-NMR spectra. Furthermore, the antimicrobial, and spasmogenic activities of some fractions and isolates were also assessed.
Keywords
Cichorium intybus L.; Lactuaceae; Asteraceae; chemical constituents; new sesquiterpene lactone; antimicrobial; spasmogenic activities;
Citations & Related Records

Times Cited By SCOPUS : 3
연도 인용수 순위
1 Abdel Salam, N. A., Mahmoud, Z. F. and Kassem, F. K., Sesquiterpene lactones, coumarins and flavonoids of Launaea tenuiloba Boiss. grown in Egypt. Egypt. J. Pharm. Sci., 27(1), 275-282 (1986)
2 Crellin, J. K. and Philpatt, J.; A Reference Guide to Medicinal Plants, Herbal Medicine Past and Present, Duke University Press, Durham and London (1990)
3 Hertog, M. G. L., Hollman, P. C. H. and Kotan, M. B., Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J. Agric. Food Chem, 40, 2379- 2383 (1992)   DOI
4 Markham, K. R., Ternal, B., Stanly, R., Geiger, H. and Mabry, T.J., Carbon 13 NMR studies of flavonoids III. Naturally occurring flavonoid glycosides and their acetylated derivatives, Tetrahedron, 34, 1389-1397 (1978)   DOI   ScienceOn
5 Yamoguchi, K., Spectral Data of Natural Products, Vol. 1, Elsevier publishing Co. Amsterdam, London, New York (1970)
6 Jian, S. R. and Kar, A., The antibacterial activity of some essential oils and their combinations, Planta Med., 20(2), 118-122 (1971)   DOI
7 Steven, F. and Tyler, V. E., Tylers Honest Herbal, A Sensible Guide to the use of Herbs Related to Remedies, 4$^{th}$ Ed., The Hawarth Herbal Press (1992)
8 Tyler, V. E., Brady, L. R. and Robbers, J. E., Pharmacognosy, 9$^{th}$ ed, Lea and Febiger, Philadelphia, 467 (1988)
9 Aboul-Ela, M. A., Abdul-Ghani, M. M., El-Fikky, F. K., Lakany, A. M. and Ghazy, N. M., Chemical constituents of Cirisum Syriacum and Chichorium intybus (Asteraceae) Growing in Egypt. Alex. J. Pharm. Sci., 16(2), 152-156 (2002)   DOI
10 Jay, M. and Gonnet, J. F., Isoscutellareine isolee de Pinguicula vulgaris. Phytochemistry, 12, 953-954 (1973)   DOI   ScienceOn
11 Williams, D. H. and Fleming, L., Spectroscopic Methods in Organic Chemistry, 3$^{rd}$ ed., McGraw Hill Book Company (UK) Limited (1980)
12 Fetrow, C. W. and Avila, J. R., Professional Handbook of complementary medicines, Spring House Corporation (1999)
13 Berry, W. L. M., Pharmacological experiments on isolated organ preparations, 2$^{nd}$ ed., E. and S. Livingstone, Edinburgh and London (1970)
14 Khalil, A. T., Abd-El-Fattah, H. and Mansour, E. S., Guaianolides from Lactuca saligna, Planta Med., 57, 190-191 (1991)   DOI   PUBMED   ScienceOn
15 Hertog, M. G. L., Hollman, P.C.H. and Venema. D. P., Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoids in vegetables and fruits. J. Agric. Food Chem, 40, 1591-1598 (1992)   DOI
16 El-Masry, S., Ghazy, N. M., Zdero, C. and Bohlmann, F., Two guaianolides from Cichorium pumilum, Phytochemistry, 23(1), 183-5 (1984)   DOI   ScienceOn
17 Amer, M. M. A., Ph.D. Thesis, The Pharmacognostical Study and Phytochemical Investigation of Certain Plants Belonging to Family Compositae, Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria, Egypt (1974)
18 Kisiel, W.; Brszez, B. and Szneler, E., Sesquiterpene lactones from Lactuca tatarica, Phytochemistry, 45(2), 365-368 (1997)   DOI   ScienceOn