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Anti-inflammatory Flavonoids: Modulators of Proinflammatory Gene Expression  

Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
Son, Kun-Ho (Department of Food and Nutrition, Andong National University)
Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University)
Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
Publication Information
Natural Product Sciences / v.10, no.1, 2004 , pp. 1-10 More about this Journal
Abstract
Plant flavonoids possess anti-inflammatory activity in vitro and in vivo. Although the action mechanisms are not fully understood, recent studies have clearly shown that certain flavonoids, especially flavone derivatives, express their anti-inflammatory activity at least in part by modulation of proinflammatory gene expression such as cyclooxygenase-2, inducible nitric oxide synthase and various cytokines. This review summarizes the recent findings of flavonoids modulating expression of proinflammatory molecules.
Keywords
Flavonoid; inflammation; gene expression; phospholipase; cyclooxygenase; nitric oxide synthase; interleukin;
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