Screening of Sterol Biosynthesis Inhibitors from Natural Products Using Recombinant Yeast Carrying Human Lanosterol Synthase
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Sung, Chung-Ki
(College of Pharmacy, Chonnam National University and Research Institute of Drug Development)
Kim, Eun-A (College of Pharmacy, Chonnam National University) Chu, Yun-Ho (College of Pharmacy, Chonnam National University) Shibuya, Masaaki (Graduate School of Pharmaceutical Sciences, The University of Tokyo) Ebizuka, Yutaka (Graduate School of Pharmaceutical Sciences, The University of Tokyo) |
1 | Kusano, M., Shibuya, M., Sankawa, U., and Ebizuka, U., Molecular cloning of cDNA encoding rat 2, 3-oxidosqualene : lanosterol cyclase. Biol. Pharm. Bull. 18, 195-197 (1995) DOI ScienceOn |
2 | Sonoda, Y., Sekigawa, Y., and Sato, Y., In vitro effects of oxygenated lanosterol derivatives on cholesterol biosynthesis from 24,25-dihydrolanosterol. Chem. Pharm. Bull., 36(3), 966-973 (1988) DOI ScienceOn |
3 | Paul, R et al., On the mechanism of hypocholesterolemia effects of polyunsaturated lipids. Adv. Lipid Res., 17, 155 (1980) PUBMED |
4 | Yamamoto, A. et al., Effects of probucol on homozygous cases of familial hypercholesterolemia. Atherosclerosis, 48, 157 (1983) DOI ScienceOn |
5 | Hashim, S. A and Van Itallie, T. B., Cholestyramine resin therapy for hypercholesteremia: Clinical and metabolic studies. JAMA, 192, 289-293 (1965) DOI |
6 | Jakobisiak, M., Bruno, S., Skierski, J. S., and Darzynkiewicz, Z., Cell cycle-specific effects of lovastatin. Proc. Natl. Acad. Sci. USA. 88, 3628-3632 (1991) DOI ScienceOn |
7 | Sung, C. K, Shibuya, M., Sankawa, U; and Ebizuka, Y., Molecular cloning of cDNA encoding human lanosterol synthase. Biol. Pharm. Bull. 18, 1459-1461 (1995) DOI ScienceOn |
8 | Horie, M., Sawasaki, Y., Fukuzumi, H., Watanabe, K., lizuka, Y., Tsuchiya, Y. and Kamei, T., Hypolipidemic effects of NB-598 in dogs. Atherosclerosis, 88, 183-192 (1991) DOI PUBMED |
9 | Rodwell, V. W., Nordstorm, J. L., and Mitschelen, J. J., Regulation of HMG-CoA reductase. Adv. Lipid. Res. 14, 1-74 (1976) |
10 | Mittinen, T. A., Mode of action of new hypocholesterolemia. Atherosclerosis, 15, 163 (1972) DOI PUBMED ScienceOn |
11 | Taton, M., Benveniste, P., and Rahier, A., Inhibition of 2,3oxidosqualene cyclases. Biochemistry, 31, 7892-7898 (1992) DOI ScienceOn |
12 | Habenicht, A J. R, Glomset, J. A, and Ross, R., Regulation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and Swiss 3T3 cells stimulated to divide by plateletderived growth factor. J. Biol. Chern. 255, 5134-5140 (1980) |
13 | Steward, J. M. et al., Effects of bezafibrate on receptor mediated and receptor independent low density lipoprotein catabolism in type II hyperlipoproteinemic subjects. Atherosclerosis, 44, 355 (1982) DOI ScienceOn |
14 | Dietschy, J. M., and Wilson, J. D., Regulation of cholesterol metabolism. New. Engl. J. Med. 282,1179-1183 (1970) DOI ScienceOn |
15 | Shepherd, J., Packard, C. J., Bicker, S., Lawrie, D. V. and Morgan, H. G., Cholestyramine promotes receptor-mediated low-densitylipoprotein catabolism. N. Eng. l. Med., 302,1219-1222 (1980) DOI ScienceOn |
16 | Biller, S. A, Sofia, M. J., DeLange, B., Forster, C, Gordon, E. M., Harrity, T., Rich, L. C. and Ciosek, C. P. Jr., The first potent inhibitor of squalene synthase: A profound contribution of an ether oxygen to inhibitor-enzyme interaction. J. Am. Chem. Soc., 113(22), 8522-8524 (1991) DOI |
17 | Maltese, W. A, and Sheridan, K. M., Differentiation of neuroblastoma cells induced by a inhibitor of mevalonate synthesis: relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis. J. Cell. Physiol. 125, 540-558 (1985) DOI PUBMED |
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