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Superoxide and Hydrogen Peroxide Scavenging Action of Ocimum Sanctum Extracts and their Fractions  

Geetha, S. (University Grant Commission Teacher Research Fellow, Department of Biochemistry, Kasturba Medical College, MAHE)
Kedlaya, R. (Department of Biochemistry, Kasturba Medical College, MAHE)
Vasudevan, D.M. (Principal, Amrita Institute of Medical Sciences and Research Center)
Publication Information
Natural Product Sciences / v.9, no.4, 2003 , pp. 223-225 More about this Journal
Abstract
Ocimum sanctum, the Indian holy basil has significant abilities to scavenge highly reactive free radicals. Shade dried leaf powder of plant has extracted with water and alcohol, fractionated with different solvents. Both extracts and their fractions were found to be good scavengers of Superoxide and hydrogen peroxide. Free radical scavenging action of these compared with ascorbic acid, a known antioxidant.
Keywords
Ocimum sanctum; antioxidant;
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1 Alho, H., Leinonen, J, Methods in Enzymology, Academic press, New York. 299, 3 (1999)
2 Ganasoundari, A., Uma Devi, P. and Rao, M.N.A., Protection against radiation-induced chromosome damage in mouse bone marrow by Ocimum sanctum. Mutat Res, 373,271 (1997)   DOI
3 Satyavathi, G. V, Gupta, K. A., Tandon, N., (eds.), Medicinal Plants of India, ICMR New Delhi. 2, 354 (1987)
4 Weiss, J. F, Landauer, M. R., Radioprotection by Antioxidants. Ann. N. .Y Acad. Sci. 899,44-55 (2000)   DOI   ScienceOn
5 Skaltsa, H., Tzakou, O., Singh, M., Polyphenols of Ocimum sanctum from Suriname. Pharmaceutical Biol. 37(1), 92-94 (1999)   DOI   ScienceOn
6 Shimoi, K., Masuda, S., Shen, B., Furugori, M., Kinae, N., Radioprotective effect of antioxidative plant Flavonoids in mice. Mutat. Res. 350, 153-161 (1996)   DOI   ScienceOn
7 Suffness, M., Douros.J, Methods in cancer Research, De Vita, V.T., Busch, H., (eds.) Academic Press New York. 116,79-83 (1979)
8 Narla, R. S., Rao, M.N.A., Scavenging of Free-radicals and Inhibition of Lipid Peroxidation by 3-Phenylsydnone. J. Pharm. Phannacol. 47,623-624 (1995)
9 Uma Devi, P and Ganasoundari, A., Radioprotective effect of leaf extract of Indian medicinal plant Ocimum sanctum. Indian J Exp Biol, 33, 205 (1995)
10 Liu, E, Ooi, V.E.C., Chang, T., Free radical scavenging activities of mushroom polysaccharide extracts. Life Sciences, 60(10), 763-771(1997)   DOI   ScienceOn
11 Uma Devi, P. and Ganasoundari, A., Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury. Indian J Exp Biol, 37, 262, (1999)
12 Ganasoundari, A., Uma Devi, P and Rao, B.S.S., Enhancement of bonemarrrow radiation protection and reduction in WR-2721 toxicity by Ocimum sanctum. Mutat Res, 397, 303 (1998)   DOI
13 Paya, M., Halliwell. B., Hoult, J.R.S., Intraction of a series of coumarins with reactive oxygen species. Scavenging of Superoxide, hydrochlorous acid and hydroxyl radicals. Biochem Phannacol, 44, 205 (1992)   DOI   ScienceOn
14 Uma devi, P, Ganasoundari, A., Vrinda, B., Srinivasan, K.K. and Unnikrishnan, M. K., Radiation protection by the Ocimum Flavonoids orientin and vicenin mechanisms of Action. Radiat Res, 154, 455 (2000)   DOI   ScienceOn