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Antioxidant Activities of Decursinol Angelate and Decursin from Angelica gigas Roots  

Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University,College of Pharmacy, Seoul National University)
Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University)
Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University)
Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
Kim, Bak-Kwang (College of Pharmacy, Seoul National University)
Kang, Sam-Sik (Natural Products Research Institute, Seoul National University,College of Pharmacy, Seoul National University)
Publication Information
Natural Product Sciences / v.9, no.3, 2003 , pp. 170-173 More about this Journal
Abstract
The anti-oxidant activities of decursinol angelate (1) and decursin (2) isolated from Angelica gigas were investigated. These two coumarins exhibited decrease in serum transaminase activities elevated by hepatic damage induced by $CCl_4-intoxication$ in rats. They also showed increase in anti-oxidant enzyme such as hepatic cytosolic superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-px) in $CCl_4-intoxicated$ rats. These results suggest that decursinol angelate (1) and decursin (2) from A. gigas possess not only the anti-oxidant, but also the hepatoprotective activities in rats.
Keywords
Angelica gigas; Umbelliferae; anti-oxidant enzymes; decursinol angelate; decursin; s-transaminase; $CCl_4-intoxication$;
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Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 9
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